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From the Townsend Letter
April 2016

Chronic Wound/Diabetic Ulcer Healing/Surgical Healing: A New Plant-Based Treatment Clinically Effective in Just 30 Days
by Brian Scott Peskin, BSc; Amid Habib, MD;
and Jeff Matheson, MD

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1.      Statistics about diabetes [Web page]. American Diabetes Association. June 10, 2014.
2.      Diabetic foot ulcers [online report]. Agency for Healthcare Research and Quality.
3.      Huge burden of foot ulcers doubles diabetes [online article]. Medscape.
4.      Robbins JM et al. Mortality rates and diabetic foot ulcers: is it time to communicate mortality risk to patients with diabetic foot ulceration?
J Am Podiatr Med Assoc. 2008;98(6):489–493.
5.      Armstrong DG et al. Guest editorial: are diabetes related wounds and amputations worse than cancer?
Int Wound J. 2007;4(4):286–287.
6.      Armstrong D. Mind the gap: Disparity between research funding and costs of care for diabetic foot ulcers.
Diabetes Care. 2013;36. 1815–1817. Ref.: Driver, VR, Fabbi M, et al. The costs of diabetic foot: the economic case for the limb salvage team. J Am Podiatr Med Assoc. 2010;100:335–341; Laing P. The development and complications of diabetic foot ulcers. Am J Surg. 1998;176(2A Suppl.):11S–19S.
7.      Fife CE. Is HBOT cost-effective for diabetic foot ulcers?
Podiatry Today. 2009;22(6).
8.      Greer N et al. Advanced wound care therapies for non-healing diabetic, venous, and arterial ulcers: A systematic review. Washington DC: Department of Veteran Affairs; 2012.
9.      Fife CE, Carter MJ, et al. Wound care outcomes and associated cost among patients treated in US outpatient wound centers.
Wounds. 2012;24(1).
10.    "Current results show that substituting w-3 fatty acid [fish oil] for w-6 fatty acids in the diet is deleterious to the mechanical properties of wounds at 30 days." Ref.: Albina JE et al. Detrimental effect of an w-3 fatty–acid enriched diet on wound healing.
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17.    Asp ML et al. Time-dependent effects of safflower oil [LA] to improve glycemia, inflammation and blood lipids in obese, post-menopausal women with type 2 diabetes: A randomized, double-masked, crossover study.
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18.    Kahleova H et al. Vegetarian diet-induced increase in linoleic acid [LA] in serum phospholipids is associated with improved insulin sensitivity in subjects with type 2 diabetes.
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19.    Dutta-Roy A. Effect of evening primrose oil feeding on erythrocyte membrane properties in diabetes mellitus. In: Horrobin D, ed.
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20.    Das UN. A defect in the activity of D6 and D5 desaturases may be a factor in the initiation and progression of atherosclerosis.
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21.    Weiss has noted that PGE1 – a metabolite maximized by GLA – reduces fibrin deposition associated with the pathogenesis of atherosclerosis. Ref.: Weiss C et al. Hemostasis and fibrinolysis in patients with intermittent claudication: effects of prostaglandin E1.
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22.    Terano T et al. Effect of oral administration of highly purified eicosapentaenoic acid on platelet function, blood viscosity and red cell deformability in healthy human subjects.
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23.    Felton CV et al. Relation of plaque lipid composition and morphology to the stability of human aortic plaques.
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24.    "[O]mega-6 PUFAs also have powerful anti-inflammatory properties that counteract any proinflammatory activity," say the advisory authors. "It's incorrect to view the omega-6 fatty acids as 'proinflammatory.'" Ref.: Farvid MS et al. Dietary linoleic acid [LA/ parent omega-6] and risk of coronary heart disease: a systematic review and meta-analysis of prospective cohort studies.
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25.    Campos H et al. Alpha-linolenic acid and risk of nonfatal acute myocardial infarction.
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