|Chronic Wound/Diabetic Ulcer Healing/Surgical Healing: A New Plant-Based Treatment Clinically Effective in Just 30 Days
by Brian Scott Peskin, BSc; Amid Habib, MD;
and Jeff Matheson, MD
Page 1, 2
1. Statistics about diabetes [Web page]. American Diabetes Association. June 10, 2014. http://www.diabetes.org/diabetes-basics/statistics.
2. Diabetic foot ulcers [online report]. Agency for Healthcare Research and Quality. http://www.effectivehealthcare.ahrq.gov/ehc/products/225/508/Data-Points_1_Diabetic-Foot-Ulcers_Report_02-2011.pdf.
3. Huge burden of foot ulcers doubles diabetes [online article]. Medscape. http://www.medscape.com/viewarticle/821908.
4. Robbins JM et al. Mortality rates and diabetic foot ulcers: is it time to communicate mortality risk to patients with diabetic foot ulceration? J Am Podiatr Med Assoc. 2008;98(6):489–493.
5. Armstrong DG et al. Guest editorial: are diabetes related wounds and amputations worse than cancer? Int Wound J. 2007;4(4):286–287.
6. Armstrong D. Mind the gap: Disparity between research funding and costs of care for diabetic foot ulcers. Diabetes Care. 2013;36. 1815–1817. Ref.: Driver, VR, Fabbi M, et al. The costs of diabetic foot: the economic case for the limb salvage team. J Am Podiatr Med Assoc. 2010;100:335–341; Laing P. The development and complications of diabetic foot ulcers. Am J Surg. 1998;176(2A Suppl.):11S–19S.
7. Fife CE. Is HBOT cost-effective for diabetic foot ulcers? Podiatry Today. 2009;22(6).
8. Greer N et al. Advanced wound care therapies for non-healing diabetic, venous, and arterial ulcers: A systematic review. Washington DC: Department of Veteran Affairs; 2012.
9. Fife CE, Carter MJ, et al. Wound care outcomes and associated cost among patients treated in US outpatient wound centers. Wounds. 2012;24(1).
10. "Current results show that substituting w-3 fatty acid [fish oil] for w-6 fatty acids in the diet is deleterious to the mechanical properties of wounds at 30 days." Ref.: Albina JE et al. Detrimental effect of an w-3 fatty–acid enriched diet on wound healing. J Parenter Enteral Nutr. 1993;17(6):519–521.
11. Libby P. Inflammation in atherosclerosis. Nature. 2002 Dec 19–26;420(6917):868–874.
12. Guo S, DiPietro LA. Factors affecting wound healing. J Dent Res. 2010;89(3):219–229.
13. Peskin BS. Cancer and mitochondrial defects: new 21st century research, Townsend Lett. August/September 2009:87–90.
14. Murray RK et al. Harper's Illustrated Biochemistry. 26th ed. New York: McGraw-Hill; 2003:97; Guyton AC, Hall JE. Textbook of Medical Physiology. 9th ed. W.B. Saunders Co.; 1996:16,861–862.
15. Krebs, JJ, Hauser H, Carafoli E, Asymmetric distribution of phospholipids in the inner membrane of beef heart mitochondria. J Biol Chem. 1979;254:5308–5316; Zhang M et al. Gluing the respiratory chain together: cardiolipin is required for supercomplex formation in the inner mitochondrial membrane. J Biol Chem. 2002;277:43553–43556.
16. Alberts B et al. Molecular Biology of the Cell. 3rd ed. Garland Science; 1994:428.
17. Asp ML et al. Time-dependent effects of safflower oil [LA] to improve glycemia, inflammation and blood lipids in obese, post-menopausal women with type 2 diabetes: A randomized, double-masked, crossover study. Clin Nutr. 2011 Aug;30(4):443–449.
18. Kahleova H et al. Vegetarian diet-induced increase in linoleic acid [LA] in serum phospholipids is associated with improved insulin sensitivity in subjects with type 2 diabetes. Nutr Diabetes 2013;3(6)e 75.
19. Dutta-Roy A. Effect of evening primrose oil feeding on erythrocyte membrane properties in diabetes mellitus. In: Horrobin D, ed. Omega-6 Essential Fatty Acids: Pathophysiology and Roles in Clinical Medicine. New York: Wiley-Liss; 1990:505–511.
20. Das UN. A defect in the activity of D6 and D5 desaturases may be a factor in the initiation and progression of atherosclerosis. Prostaglandins Leukot Essent Fatty Acids. 2007;76(5):251–268.
21. Weiss has noted that PGE1 – a metabolite maximized by GLA – reduces ﬁbrin deposition associated with the pathogenesis of atherosclerosis. Ref.: Weiss C et al. Hemostasis and ﬁbrinolysis in patients with intermittent claudication: effects of prostaglandin E1. Prostaglandins Leukot Essent Fatty Acids. 2000;63:271–277.
22. Terano T et al. Effect of oral administration of highly purified eicosapentaenoic acid on platelet function, blood viscosity and red cell deformability in healthy human subjects. Atherosclerosis. 1983;46:321–331.
23. Felton CV et al. Relation of plaque lipid composition and morphology to the stability of human aortic plaques. Arterioscler Thromb Vasc Biol. 1997;17(7):1337–1345.
24. "[O]mega-6 PUFAs also have powerful anti-inflammatory properties that counteract any proinflammatory activity," say the advisory authors. "It's incorrect to view the omega-6 fatty acids as 'proinflammatory.'" Ref.: Farvid MS et al. Dietary linoleic acid [LA/ parent omega-6] and risk of coronary heart disease: a systematic review and meta-analysis of prospective cohort studies. Circulation. 2014;130:1568–1578.
25. Campos H et al. Alpha-linolenic acid and risk of nonfatal acute myocardial infarction. Circulation. 2008;118:339–345.
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