Townsend Letter Alternative Medicine Magazine

 

 

  FREE e-Edition

 

 EDTA Chelation Therapy

 

 E-mail List

 

 TLDP.com


From the Townsend Letter
December 2015

Nutritional Antioxidants and Testosterone Secretion: Natural Methods to Increase Testosterone in Men
by Michael J. Glade, PhD; Kyl Smith, DC; and Michael M. Meguid, MD, PhD
Search this site

Page 1, 2

Notes
1.   Glade MJ, Smith K. 2015. Oxidative stress, nutritional antioxidants, and testosterone secretion in men. Ann Nutr Dis Ther. 2015;2:1019.
2.   Cao L, Leers-Sucheta S, Azhar S. Aging alters the functional expression of enzymatic and non-enzymatic anti-oxidant defense systems in testicular rat Leydig cells. J Steroid Biochem Mol Biol. 2004;88:61–67.
3.   Chen H, Ge RS, Zirkin BR. Leydig cells: From stem cells to aging. Mol Cell Endocrinol. 2009;306:9–16.
4.   Murugesan P, Muthusamy T, Balasubramanian K, Arunakaran J. Studies on the protective role of vitamin C and E against polychlorinated biphenyl (Aroclor 1254)-induced oxidative damage in Leydig cells. Free Radic Res. 2005;39:1259–1272.
5.   Murugesan P, Muthusamy T, Balasubramanian K, Arunakaran J. Effects of vitamins C and E on steroidogenic enzymes mRNA expression in polychlorinated biphenyl (Aroclor 1254) exposed adult rat Leydig cells. Toxicology. 2007a;232:170–182.
6.   Murugesan P, Balaganesh M, Balasubramanian K, Arunakaran J. Effects of polychlorinated biphenyl (Aroclor 1254) on steroidogenesis and antioxidant system in cultured adult rat Leydig cells. J Endocrinol. 2007b;192:325–338.
7.   Ye L, Su ZJ, Ge RS. Inhibitors of testosterone biosynthetic and metabolic activation enzymes. Molecules. 2011;16:9983–10001.
8.   Miller WL, Auchus RJ. The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders. Endocr Rev. 2011;32:81–151.
9.   Tai P, Ascoli M. Reactive oxygen species (ROS) play a critical role in the cAMP-induced activation of Ras and the phosphorylation of ERK1/2 in Leydig cells. Mol Endocrinol. 2011;25:885–893.
10. Luo L, Chen H, Trush MA, Show MD, Anway MD, Zirkin BR. Aging and the brown Norway rat Leydig cell antioxidant defense system. J Androl. 2006;27:240–47.
11. Glade MJ, Smith K, Meguid MM. A glance at…nutritional antioxidants and testosterone secretion. Nutrition. 2015;31:1295–1298.
12. Chen H, Pechenino AS, Liu J, Beattie MC, Brown TR, Zirkin BR. Effect of glutathione depletion on Leydig cell steroidogenesis in young and old brown Norway rats. Endocrinology. 2008;149:2612–2619.
13. Chang MS, Kim WN, Yang WM, Kim HY, Oh JH, Park SK. Cytoprotective effects of Morinda officinalis against hydrogen peroxide-induced oxidative stress in Leydig TM3 cells. Asian J Androl. 2008;10:667–674.
14. Gautam DK, Misro MM, Chaki SP, Sehgal N. H2O2 at physiological concentrations modulates Leydig cell function inducing oxidative stress and apoptosis. Apoptosis. 2006;11:39–46.
15. Chen H, Zhou L, Lin CY, Beattie MC, Liu J, Zirkin BR. Effect of glutathione redox state on Leydig cell susceptibility to acute oxidative stress. Mol Cell Endocrinol. 2010;323:147–154.
16. Diemer T, Allen JA, Hales KH, Hales DB. Reactive oxygen disrupts mitochondria in MA-10 tumor Leydig cells and inhibits steroidogenic acute regulatory (StAR) protein and steroidogenesis. Endocrinology. 2003;144:2882–2891.
17. Allen JA, Shankara T, Janus P, Buck S, Diemer T, Hales KH, et al. Energized, polarized, and actively respiring mitochondria are required for acute Leydig cell steroidogenesis. Endocrinology. 2006;147:3924–3935.
18. Zaidi SK, Shen WJ, Bittner S, Bittner A, McLean MP, Han J, Davis RJ, Kraemer FB, Azhar S. p38 MAPK regulates steroidogenesis through transcriptional repression of STAR gene. J Mol Endocrinol. 2014;53:1–16.
19. Veldhuis JD. Recent insights into neuroendocrine mechanisms of aging of the human male hypothalamic-pituitary-gonadal axis. J Androl 1999a;. 20:1–17.
20. Luboshitzky R, Shen-Orr Z, Herer P. Middle-aged men secrete less testosterone at night than young healthy men. J Clin Endocrinol Metab. 2003;88:3160–3166.
21. Mulligan T, Iranmanesh A, Johnson ML, Straume M, Veldhuis JD. Aging alters feed-forward and feedback linkages between LH and testosterone in healthy men. Am J Physiol 1997;273:R1407–R1413.
22. Murugesan P, Muthusamy T, Balasubramanian K, Arunakaran J. Polychlorinated biphenyl (Aroclor 1254) inhibits testosterone biosynthesis and antioxidant enzymes in cultured rat Leydig cells. Reprod Toxicol. 2008;25:447–454.
23. Aitken RJ, Roman SD. Antioxidant systems and oxidative stress in the testes. Oxid Med Cell Longev. 2008;1:15–24.
24. Chigurupati S, Son TG, Hyun DH, Lathia JD, Mughal MR, Savell J, et al. Lifelong running reduces oxidative stress and degenerative changes in the testes of mice. J Endocrinol. 2008;199:333–341.
25. Al-Olayan EM, El-Khadragy MF, Metwally DM, Abdel Moneim AE. Protective effects of pomegranate (Punica granatum) juice on testes against carbon tetrachloride intoxication in rats. BMC Complement Altern Med. 2014;14:164.
26. Ceribası AO, Sakin F, Türk G, Sönmez M, Ateşşahin A. Impact of ellagic acid on adriamycin-induced testicular histopathological lesions, apoptosis, lipid peroxidation and sperm damages. Exp Toxicol Pathol. 2012;64:717–724.
27. Hermsdorff HH, Barbosa KB, Volp AC, et al. Vitamin C and fibre consumption from fruits and vegetables improves oxidative stress markers in healthy young adults. Br J Nutr. 2012;107:1119–1127.
28. Karanth S, Yu WH, Walczewska A, Mastronardi CA, McCann SM. Ascorbic acid stimulates gonadotropin release by autocrine action by means of NO. Proc Natl Acad Sci U S A. 2001;98:11783–11788.
29. Vijayprasad S, Bb G, Bb N. Effect of vitamin C on male fertility in rats subjected to forced swimming stress. J Clin Diagn Res. 2014;8:HC05–HC08.
30. Sen Gupta R, Sen Gupta E, Dhakal BK, Thakur AR, Ahnn J. Vitamin C and vitamin E protect the rat testes from cadmium-induced reactive oxygen species. Mol Cells. 2004;17:132–139.
31. Ayinde OC, Ogunnowo S, Ogedegbe RA. Influence of Vitamin C and Vitamin E on testicular zinc content and testicular toxicity in lead exposed albino rats. BMC Pharmacol Toxicol. 2012;13:17.
32. Das UB, Mallick M, Debnath JM, Ghosh D. Protective effect of ascorbic acid on cyclophosphamide-induced testicular gametogenic and androgenic disorders in male rats. Asian J Androl. 2002;4:201–207.
33. Ghosh D, Das UB, Misro M. Protective role of alpha-tocopherol-succinate (provitamin-E) in cyclophosphamide induced testicular gametogenic and steroidogenic disorders: A correlative approach to oxidative stress. Free Radic Res. 2002a;36:209–218.
34. Ghosh D, Das UB, Ghosh S, Mallick M, Debnath J. Testicular gametogenic and steroidogenic activities in cyclophosphamide treated rat: A correlative study with testicular oxidative stress. Drug Chem Toxicol. 2002b;25:281–292.
35. Chang SI, Jin B, Youn P, Park C, Park JD, Ryu DY. Arsenic-induced toxicity and the protective role of ascorbic acid in mouse testis. Toxicol Appl Pharmacol. 2007;218:196–203.
36. Meydani SN, Han SN, Wu D. Vitamin E and immune response in the aged: Molecular mechanisms and clinical implications. Immunol Rev. 2005;205:269–284.
37. Mukhopadhyay PK, Dey A, Mukherjee S, Pradhan NK. The effect of coadministration of a-tocopherol and ascorbic acid on arsenic trioxide-induced testicular toxicity in adult rats. J Basic Clin Physiol Pharmacol. 2013;24:245–253.
38. Chen H, Liu J, Luo L, Baig MU, Kim JM, Zirkin BR. Vitamin E, aging and Leydig cell steroidogenesis. Exp Gerontol. 2005;40:728–736.
39. Manna I, Jana K, Samanta PK. Intensive swimming exercise-induced oxidative stress and reproductive dysfunction in male wistar rats: Protective role of a-tocopherol succinate. Can J Appl Physiol. 2004a;29:172–185.
40. Jahan S, Zahra A, Irum U, Iftikhar N, Ullah H. Protective effects of different antioxidants against cadmium induced oxidative damage in rat testis and prostate tissues. Syst Biol Reprod Med. 2014a;60:199–205.
41. Jahan S, Khan M, Ahmed S, Ullah H. Comparative analysis of antioxidants against cadmium induced reproductive toxicity in adult male rats. Syst Biol Reprod Med. 2014b;60:28–34.
42. Chandra AK, Chatterjee A, Ghosh R, Sarkar M. Vitamin E-supplementation protect chromium (VI)-induced spermatogenic and steroidogenic disorders in testicular tissues of rats. Food Chem Toxicol. 2010;48:972–979.
43. El-Shenawy NS, Al-Harbi MS, Hamza RZ. Effect of vitamin E and selenium separately and in combination on biochemical, immunological and histological changes induced by sodium azide in male mice. Exp Toxicol Pathol. 2015;67:65–76.
44. Umeda F, Kato K, Muta K, Ibayashi H. Effect of vitamin E on function of pituitary-gonadal axis in male rats and human subjects. Endocrinol Jpn 1982;29:287–292.
45. El-Beshbishy HA, Aly HA, El-Shafey M. Lipoic acid mitigates bisphenol A-induced testicular mitochondrial toxicity in rats. Toxicol Ind Health. 2013;29:875–887.
46. Nanjappa MK, Simon L, Akingbemi BT. The industrial chemical bisphenol A (BPA) interferes with proliferative activity and development of steroidogenic capacity in rat Leydig cells. Biol Reprod. 2012;86: 35, 1–12.
47. Prasad AS, Mantzoros CS, Beck FW, Hess JW, Brewer GJ. Zinc status and serum testosterone levels of healthy adults. Nutrition 1996;12:344–348.
48. Amara S, Abdelmelek H, Garrel C,  et al. Preventive effect of zinc against cadmium-induced oxidative stress in the rat testis. J Reprod Dev. 2008;54:129–134.
49. Behne D, Weiler H, Kyriakopoulos A. Effects of selenium deficiency on testicular morphology and function in rats. J Reprod Fertil 1996;106:291–297.
50. Abarikwu SO, Iserhienrhien BO, Badejo TA. Rutin- and selenium-attenuated cadmium-induced testicular pathophysiology in rats. Hum Exp Toxicol. 2013;32:395–406.
51. El-Maraghy SA, Nassar NN. Modulatory effects of lipoic acid and selenium against cadmium-induced biochemical alterations in testicular steroidogenesis. J Biochem Mol Toxicol. 2011;25:15–25.
52. Erkekoglu P, Zeybek ND, Giray B, Asan E, Arnaud J, Hincal F. Reproductive toxicity of di(2-ethylhexyl) phthalate in selenium-supplemented and selenium-deficient rats. Drug Chem Toxicol. 2011;34:379–389.
53. Coniglio JG, Grogan WM Jr, Rhamy RK. Lipids of human testes removed at orchidectomy. J Reprod Fertil 1974;41:67–73.
54. Cooke GM. Identification and mechanism of action of phospholipids capable of modulating rat testicular microsomal 3b-hydroxysteroid dehydrogenase-isomerase activity in vitro. Biol Reprod 1989;41:438–445.
55. Rasmussen MK, Ekstrand B, Zamaratskaia G. Regulation of 3b-hydroxysteroid dehydrogenase/∆5-∆4 isomerase: A review. Int J Mol Sci. 2013;14:17926–17942.
56. Huang BX, Akbar M, Kevala K, Kim HY. Phosphatidylserine is a critical modulator for Akt activation. J Cell Biol. 2011;192:979–992.
57. Starks MA, Starks SL, Kingsley M, Purpura M, Jäger R. The effects of phosphatidylserine on endocrine response to moderate intensity exercise. J Int Soc Sports Nutr. 2008;5:11.

 

Michael J. Glade, PhD
The Nutrition Doctor
Kailua-Kona, Hawaii

Kyl Smith, DC
Progressive Laboratories Inc.
Irving, Texas

Michael M. Meguid, MD, PhD, MFA, FACS, Professor Emeritus, Surgery, Neuroscience and Nutrition
Department of Surgery, University Hospital, Upstate Medical University
750 E. Adams Street
Syracuse, New York 13210
 
Corresponding Author
Kyl Smith, DC
Progressive Laboratories Inc.
3131 Story Road W.
Irving, Texas 75038
972-518-9660
drkyl@progressivelabs.com

Michael J. Glade, PhD, is a certified nutritional specialist (CNS) with degrees from the Massachusetts Institute of Technology (MIT) and Cornell University. Dr. Glade is a noted researcher in the nutritional and scientific communities for providing a significant body of peer-reviewed substantiation for multiple health claims that have been approved by the FDA.

Kyl Smith, DC, is the author of the book The Testosterone Switch and a popular speaker providing continuing education programs wherein he teaches doctors how to utilize diet, exercise, and nutrition to improve testosterone status in otherwise healthy men. Dr. Smith is director of education for Progressive Laboratories Inc.

Michael M. Meguid, MD, PhD, is editor-in-chief of the peer-reviewed journal Nutrition  (http://www.nutritionjrnl.com/). Dr. Meguid is professor emeritus, surgery, neuroscience and nutrition, Department of Surgery, University Hospital, Upstate Medical University. University of New York Health Science Center, Syracuse, New York.

Page 1, 2


Consult your doctor before using any of the treatments found within this site.

Subscriptions are available for Townsend Letter, the Examiner of Alternative Medicine
magazine, which is published 10 times each year. Search our pre-2001 archives for further information. Older issues of the printed magazine are also indexed for your convenience.
1983-2001 indices ; recent indices. Once you find the magazines you'd like to order, please
use our convenient form, e-mail subscriptions@townsendletter.com, or call 360.385.6021.

 

360.385.6021
Fax: 360.385.0699
info@townsendletter.com

Who are we? | New articles | Featured topics | e-Edition |
Tables of contents
| Subscriptions | Contact us | Links | Classifieds | Advertise |
Alternative Medicine Conference Calendar | Search site | Archives |
EDTA Chelation Therapy | Home

© 1983-2015 Townsend Letter
All rights reserved.
Website by Sandy Hershelman Designs