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1. Loane DJ, Faden AI. Neuroprotection for traumatic brain injury: translational challenges and emerging therapeutic strategies. Trends Pharmacol Sci. 2010 December 1;31(12):596–604.
2. Werner C, Engelhard K. Pathophysiology of traumatic brain injury. Br J Anaesth. 2007;99(1):4–9.
3. Marchi N, Bazarian JJ, Puvenna V, et al. Consequences of repeated blood-brain barrier disruption in football players. PloS ONE. March 6, 2013.
4. Zemper ED. Analysis of cerebral concussion frequency with the most commonly used models of football helmets. J Athl Train. 1994 Mar;29(1):44–50.
5. Traumatic brain injury in the United States: fact sheet [Web page]. Centers for Disease Control and Prevention. http://www.cdc.gov/traumaticbraininjury/get_the_facts.html. Accessed August 22, 2015.
6. Willer B, Dumas J, Hutson A, Leddy J. A population based investigation of head injuries and symptoms of concussion of children and adolescents in schools. Inj Prev. 2004;10:144–148.
7. Chambers J, Cohen SS, Hemminger L, et al. Mild traumatic brain injuries in low-risk trauma patients. J Trauma. 1996 Dec. 41(6):976–980.
8. Faul M et al. Traumatic Brain Injury in the United States: Emergency Department Visits, Hospitalizations and Deaths 2002–2006. Atlanta, GA: Centers for Disease Control and Prevention; 2010.
9. Bryan CJ, Clemans TA. Repetitive traumatic brain injury, psychological symptoms, and suicide risk in a clinical sample of deployed military personnel. JAMA Psychiatry. 2013;70:686–691.
10. Kolaitis G, Giannakopoulos G, Liakopoulou M, et al. Predicting pediatric posttraumatic stress disorder after road traffic accidents: the role of parental psychopathology. J Trauma Stress. 2011 Aug;24(4):414–421.
11. Mild traumatic brain injury/concussion [Web page]. Centers for Disease Control and Prevention. http://www.cdc.gov/concussion/signs_symptoms.html. Accessed Sept 8, 2015.
12. Katz RT, DeLuca J. Sequelae of minor traumatic brain injury. Am Fam Physician. 1992;46:1491–1498.
13. Block, ML, Zecca L, Hong JS. Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat Rev Neurosci. 2007 Jan;8(1):57–69.
14. Cunningham C, Wilcockson DC, Campion S, Lunnon K, Perry VH. Central and systemic endotoxin challenges exacerbate the local inflammatory response and increase neuronal death during chronic neurodegeneration. J Neurosci. 2005;25:9275–9284.
15. Macciocchi SN, Barth JT, Littlefield LM. Outcome after mild head injury. Clin Sports Med.1998;17:27–36.
16. Xiong Y, Mahmood A, Chopp M. Emerging treatments for traumatic brain injury. Expert Opin Emerg Drugs. 2009;14(1):67–84.
17. Maas AI, Roozenbeek B, Manley GT. Clinical trials in traumatic brain injury: past experience and current developments. Neurotherapeutics. 2010 Jan;7(1):115–126.
18. Ratcliff JJ, Greenspan AI, Goldstein FC, et al. Gender and traumatic brain injury: Do the sexes fare differently? Brain Inj. 2007 Sep;21(10):1023–1030.
19. Roof RL, Hall ED. Gender differences in acute CNS trauma and stroke: neuroprotective effects of estrogen and progesterone. J Neurotrauma. 2000 May;17(5):367–388.
20. Schumacher M, Hussain R, Gago N, Oudinet J-P, Mattern C, Ghoumari AM. Progesterone synthesis in the nervous system: Implications for myelination and myelin repair. Front Neurosci. 2012;6:10.
21. Roof RL, Hoffman SW, Stein DG. Progesterone protects against lipid peroxidation following traumatic brain injury in rats. Mol Chem Neuropathol. 1997 May;31(1):1–11.
22. Pettus EH, Wright DW, Stein DG, Hoffman SW. Progesterone treatment inhibits the inflammatory agents that accompany traumatic brain injury. Brain Res. 2005;1049:112–119.
23. Camacho-Arroyo I, et al. Intracellular progesterone receptors are differentially regulated by sex steroid hormones in the hypothalamus and the cerebral cortex of the rabbit. J Steroid Biochem Mol Biol. 1994;50 (5–6):299–303.
24. Signh M, Su C. Progesterone and neuroprotection. Horm Behav. 2013 Feb;63(2):284–290.
25. O'Connor CA, Cernak I, Vink R, et al. Both estrogen and progesterone attenuate edema formation following diffuse traumatic brain injury in rats. Brain Res. 2005;1062:171–174.
26. Wright DW et al. ProTECT: a randomized clinical trial of progesterone for acute traumatic brain injury. Ann Emerg Med. 2007;49(4):391–402.
27. Xiao G, Wei J, Yan W, Wang W, Lu Z. Improved outcomes from the administration of progesterone for patients with acute severe traumatic brain injury: a randomized controlled trial. Crit Care. 2008;12(2):R61.
28. Wright DW, Yeatts SD, Silbergleit R, et al. Very early administration of progesterone for acute traumatic brain injury. N Engl J Med 2014;372:2457–2466.
29. Skolnick BE, Maas AI, Narayan RK, et al. A clinical trial of progesterone for severe traumatic brain injury. N Engl J Med 2014;371:2467–2476.
30. Stein DG. Embracing failure: What the phase III progesterone studies can teach about TBI clinical trials. Brain Inj. 2015 Aug 14:1–14.
31. Michael-Titus AT Omega-3 fatty acids and neurological injury. Prostaglandins Leukot Essent Fatty Acids. 2007 Nov–Dec;77(5–6):295–300.
32. Kumar PR, Essa MM, Al-Adawi S, et al. Omega-3 fatty acids could alleviate the risks of traumatic brain injury – a mini review. J Tradit Complement Med. 2014;4(2):89–92. doi:10.4103/2225-4110.130374.
33. Mills JD, Bailes JE, Sedney CL, Hutchins H, Sears B. Omega-3 fatty acid supplementation and reduction of traumatic axonal injury in a rodent head injury model. J Neurosurg. 2011 Jan;114(1):77–84.
34. Smolders J, Moen SM, Damoiseaux J, Huitinga I, Holmøy T. Vitamin D in the healthy and inflamed central nervous system: access and function. J Neurol Sci. 2011;311:37–43.
35. Aminmansour B, Nikbakht H, Ghorbani A, et al. Comparison of the administration of progesterone versus progesterone and vitamin D in improvement of outcomes in patients with traumatic brain injury: a randomized clinical trial with placebo group. Adv Biomed Res. 2012;1:58.
36. Tiwari S, Pratyush DD, Gupta SK, Singh SK. Vitamin D deficiency is associated with inflammatory cytokine concentrations in patients with diabetic foot infection. Br J Nutr. 2014 Dec 28;112(12):1938–1943.
37. Cekic M, Cutler SM, VanLandingham JW, Stein DG. Vitamin D deficiency reduces the benefits of progesterone treatment after brain injury in aged rats. Neurobiol Aging. 2011;32:864–874.
38. McCann, JC, Ames BN. Is there convincing biological or behavioral evidence linking vitamin D deficiency to brain dysfunction. FASEB J. 2008 Apr;22(4):982–1001.
39. Ganji V, Zhang X, Tangpricha V. Serum 25-hydroxyvitamin D concentrations and prevalence estimates of hypovitaminosis D in the U.S. population based on assay-adjusted data. J Nutr. 2012;142:498–507.
40. Wentz LM. Vitamin D status may affect resilience and recovery from mild traumatic brain injury in military personnel. Austin J Nutr Food Sci. 2014;2(5):1030. ISSN: 2381-8980.
41. Wu A1, Ying Z, Gomez-Pinilla F. Dietary curcumin counteracts the outcome of traumatic brain injury on oxidative stress, synaptic plasticity, and cognition. Exp Neurol. 2006 Feb;197(2):309–317.
42. Laird MD, SR S, Swift AEB, Meiler SE, Vender JR, Dhandapani KM. Curcumin attenuates cerebral edema following traumatic brain injury in mice: a possible role for aquaporin-4? J Neurochem. 2010;113(3):637–648.
43. Zhu H, Bian C, Yuan J, et al. Curcumin attenuates acute inflammatory injury by inhibiting the TLR4/MyD88/NF-kB signaling pathway in experimental traumatic brain injury. J Neuroinflammation. 2014;11:59.
44. Anand P, Kunnumakkara, AB, Newman RA, Aggarwal BB. Bioavailability of curcumin: problems and promises. Mol Pharmaceutics. 2007;4(6):807–818.
45. Cuomo J, Appendino G, Dern AS, et al. Comparative absorption of a standardized curcuminoid mixture and its lecithin formulation. J Nat Prod. 2011 Apr 25;74(4):664–669.
Dr. Wood grew up in Colorado and obtained her undergraduate degree in biochemistry from Colorado College. An enthusiasm for science but a passion for people led her to medicine, and a desire to treat the cause of disease, not just the symptoms, led her to naturopathy. After completing her doctorate at the National College of Naturopathic Medicine, Dr. Wood stayed in Oregon and has a private practice focused on endocrine imbalance, digestive dysfunction, immune support, and cardiovascular health.
In addition to her clinical practice, Dr. Wood is a staff physician with Labrix Clinical Services Inc., where she educates physicians and health care providers around the country about hormonal balancing through development of educational materials, contributions to a webinar series, and lectures at local and national conferences. In 2008 she coauthored a book on andropause titled His Change of Life: Male Menopause and Healthy Aging with Testosterone.
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