Online
publication only
Several
foods and dietary micronutrients are associated with optimal health.
Chronic nutrient deficiencies compromise health, resulting
in disease or morbidity. Here's a challenge to readers: review
each statement's cited reference to determine if the statement has
been well-supported.
1. Fruit and vegetable consumption benefits bone health.
Prynne CJ, Mishra GD, et al. Fruit and vegetable intakes and bone mineral
status: a cross sectional study in 5 age and sex cohorts. Am
J Clin Nutr. 2006; 83(6): 1420-1428.
2. High dietary intakes of plant lignans reduce the risk of breast
cancer in premenopausal women.
Piller R, Chang-Claude J, Linseisen J. Plasma enterolactone and genistein
and the risk of premenopausal breast cancer. Eur
J Cancer Prev. 2006;
15(3): 225-32.
3. Higher intakes of plant lignans reduce the risk of colorectal adenomas.
Kuijsten A, Arts IC, et al. Plasma enterolignans are associated with
lower colorectal adenoma risk. Cancer Epidemiol
Biomarkers Prev.
2006; 15(6): 1132-6.
4. Higher intakes of vegetables, lutein, zeaxanthin, and zinc are
associated with lower risk of non-hodgkin lymphoma.
Kelemen LE, Cerhan JR, et al. Vegetables, fruit, and antioxidant-related
nutrients and risk of non-Hodgkin lymphoma: A National Cancer Institute-Surveillance,
Epidemiology, and End Results population-based case-control study.
Am J Clin Nutr. 2006; 83(6): 1401-10.
5. Higher dietary intakes of choline and betaine reduce plasma homocysteine
levels.
Cho E, Zeisel SH, et al. Dietary choline and betaine assessed by food-frequency
questionnaire in relation to plasma total homocysteine concentration
in the Framingham Offspring Study. Am J Clin
Nutr. 2006; 83(4): 905-11.
6. Eating low dietary fiber and fruits contributes to fat weight gain.
Davis JN, Hodges VA, Gillham MB. Normal-weight adults consume more
fiber and fruit than their age- and height-matched overweight/obese
counterparts. J Am Diet Assoc. 2006; 106(6): 833-40.
7. Eating dietary fiber and fruits lowers body fat.
Davis JN, Hodges VA, Gillham MB. Normal-weight adults consume more
fiber and fruit than their age- and height-matched overweight/obese
counterparts. J Am Diet Assoc. 2006; 106(6): 833-40.
8. Eating extremely well-done meat may increases the risk of prostate
cancer.
Cross AJ, Peters U, et al. A prospective study of meat and meat mutagens
and prostate cancer risk. Cancer Res. 2005; 65(24): 11779-84.
9. Supplementation with Coenzyme Q-10 reduces the effects of aging.
Yan J, Fujii K, et al. Reduced coenzyme Q10 supplementation decelerates
senescence in SAMP1 mice. Exp Gerontol. 2005, Dec 29 [Epub ahead
of print].
10. Betaine reduces plasma homocysteine.
Schwab U, Torronen A, et al. Orally administered betaine has an acute
and dose-dependent effect on serum betaine and plasma homocysteine
concentrations in healthy humans. J Nutr. 2006 136(1): 34-8.
11. Tea and coffee consumption reduces the risk of chronic liver disease.
Ruhl CE and Everhart JE. Coffee and tea consumption are associated
with a lower incidence of chronic liver disease in the United States.
Gastroenterology. 2005; 129(6): 1928-36.
12. High doses of Coenzyme Q-10 improve muscle strength in patients
with muscle Coenzyme Q-10 deficiency.
Horvath R, Schneiderat P, et al. Coenzyme Q10 deficiency and isolated
myopathy. Neurology. 2006; 66(2): 253-5.
13. Breakfast cereals reduce the risk of weight gain.
Bazzano LA, Song Y, et al. Dietary intake of whole and refined grain
breakfast cereals and weight gain in men. Obes
Res. 2005; 13(11):
1952-60.
14. Dietary supplementation with silymarin and its polyphenolic fraction
inhibits cholesterol absorption.
Sobolova L, Skottova N, et al. Effect of silymarin and its polyphenolic
fraction on cholesterol absorption in rats. Pharmacol
Res. 2006; 53(2):
104-112.
15. Long-term vitamin C supplementation reduces the frequency of the
common cold.
Sasazuki S, Sasaki S, et al. Effect of vitamin C on common cold: randomized
controlled trial. Eur J Clin Nutr. 2006; 60(1): 9-17.
16. High fish intake further reduces risk of coronary heart disease.
Intake of fish and omega-3 fatty acids and risk of coronary heart disease
among Japanese: Iso H, Kobayashi M, et al. The Japan Public Health
Center-Based (JPHC) Study Cohort I. Circulation. 2006; 113(2): 195-202.
17. Vitamin D supplementation enhances bone mineral density in subjects
with knee osteoarthritis.
Bischoff-Ferrari HA, Zhang Y, et al. Positive association between serum
25-hydroxyvitamin D level and bone density in osteoarthritis. Arthritis
Rheum. 2005; 53(6): 821-6.
18. Polyphenolic antioxidants reduce exercise-induced oxidative stress.
Morillas-Ruiz JM, Vidal-Guevara ML, et al. Effects of polyphenolic
antioxidants on exercise-induced oxidative stress. Clin
Nutr. 2006
Jan 17; [Epub ahead of print].
19. Short-term folic acid supplementation protects against atherosclerosis
and cardiovascular diseases.
Solini A, Santini E, et al. Effect of short-term folic acid supplementation
on insulin sensitivity and inflammatory markers in overweight subjects.
Int J Obes (Lond.). 2006 Feb 21; [Epub ahead of print].
20. Supplementation with carotenoids reduces lymphocyte DNA damage.
Zhao X, Yeum KJ, et al. Modification of lymphocyte DNA damage by carotenoid
supplementation in postmenopausal women. Am
J Clin Nutr. 2006; 83(1):
163-9.
21. Reducing portion size and energy density of foods decreases energy
intake without affecting hunger.
Rolls BJ, Roe LS, Meengs JS. Reductions in portion size and energy
density of foods are additive and lead to sustained decreases in energy
intake. Am J Clin Nutr. 2006; 83(1): 11-17.
22. Dietary curcumin may counteract the effects of traumatic brain
injury on synaptic plasticity and cognitive function.
Wu A, Ying Z, Gomez-Pinilla F. Dietary curcumin counteracts the outcome
of traumatic brain injury on oxidative stress, synaptic plasticity,
and cognition. Exp Neurol. 2006; 197(2): 309-17.
23. Conditionally Essential Nutrients (CEN) (taurine, coenzyme Q10,
l-carnitine [CAR], propionyl l-carnitine [PCAR], and l-arginine) are
clinically beneficial at reducing conditions associated with Cardiovascular
Heart Disease (CVD), such as chronic heart failure, myocardial infarction,
angina pectoris, hypertension, hyperlipidemia, and lipoprotein(a).
Kendler BS. Supplemental conditionally essential nutrients in cardiovascular
disease therapy. J Cardiovasc Nurs. 2006; 21(1): 9-16.
24. Omega-3 fatty acids may be effective at lowering elevated lipid
levels and reducing the risk of cardiac and overall mortality.
Studer M, Briel M, et al. Effect of different antilipidemic agents
and diets on mortality: A systematic review. Arch
Intern Med. 2005;
165(7): 725-30.
25. Glycine supplementation lowers high blood pressure.
El Hafidi M, Perez I, Banos G. Is glycine effective against elevated
blood pressure? Curr Opin Clin Nutr Metab
Care. 2006; 9(1): 26-31.
26. Salt intake acutely affects oxidative stress, particularly in
salt-sensitive hypertension.
Laffer CL, Bolterman RJ, et al. Effect of salt on isoprostanes in salt-sensitive
essential hypertension. Hypertension. 2006; 47(3): 434-40.
27. Omega-3 fatty acids may be beneficial in helping to reduce inflammatory
markers and to increase anti-inflammatory markers in the body.
Ferruci L, Cherubini A, et al. Relationship of plasma polyunsaturated
fatty acids to circulating inflammatory markers. J
Clin Endocrinol Metab. 2006; 91(2): 439-46.
28. Nut and seed consumption reduce various inflammatory markers.
Jiang R, Jacobs DR Jr., et al. Nut and seed consumption and inflammatory
markers in the multi-ethnic study of atherosclerosis. Am
J Epidemiol.
2006; 163(3): 222-31.
29. Combined supplementation with glucosamine and chondroitin sulfate
reduces moderate-to-severe knee pain in patients with knee osteoarthritis.
Clegg DO, Domenic RJ, et al. Glucosamine, chondroitin sulfate, and
the two in combination for painful knee osteoarthritis. N
Engl J Med. 2006; 354(8): 795-808.
30. Vitamin therapy (folic acid, vitamin B-12, vitamin B-6) reduces
plasma total homocysteine levels in stroke patients.
Ho GY, Eikelboom JW, et al. Methylenetetrahydrofolate reductase polymorphisms
and homocysteine-lowering effect of vitamin therapy in Singaporean
stroke patients. Stroke. 2006; 37(2): 456-60.
31. Ascorbic acid prevents hypercholesterolemia-induced atherosclerosis.
Das S, Ray R, et al. Effect of ascorbic acid on prevention of hypercholesterolemia
induced atherosclerosis. Mol Cell Biochem. 2006 Feb 14; [Epub ahead
of print].
32. Replacing saturated fatty acids with monounsaturated fatty acids
reduces blood pressure in healthy adults.
Rasmussen BM, Vessby B, et al. Effects of dietary saturated, monounsaturated,
and omega-3 fatty acids on blood pressure in healthy adults. Am
J Clin Nutr. 2006; 83(2): 221-6.
33. Increasing intakes of vegetable proteins reduces blood pressure.
Elliott P, Stamler J, et al. Association between protein intake and
blood pressure: The INTERMAP Study. Arch
Intern Med. 2006; 166(1):
70-87.
34. The protective effects of high fiber intake and fish consumption
against colorectal cancer are demonstrated by a report that daily intake
of 35 g of saturated fat doubles the risk of breast cancer compared
to women with daily intake of 10 g or less.
Gonzalez CA. The European Prospective Investigation into Cancer and
Nutrition (EPIC). Public Health Nutr. 2006; 9(1A): 124-6.
35. High consumption of processed meat increases risk of colon cancer.
Oba S, Shimizu N, et al. The relationship between the consumption of
meat, fat, and coffee and the risk of colon cancer: A prospective
study in Japan. Cancer Lett. 2006 March 3; [Epub ahead of print].
36. Low plasma vitamin E levels are associated with dementia and cognitive
impairment.
Cherubini A, Martin A, et al. Vitamin E levels, cognitive impairment,
and dementia in older persons: The InCHIANTI study. Neurobiol
Aging.
2005; 26(7): 987-94.
37. Vitamin C, along with aspirin, decreases lipid peroxidation in
ischemic stroke patients.
Polidori MC, Pratico D, et al. Effects of vitamin C and aspirin in
ischemic stroke-related lipid peroxidation: Results of the AVASAS (Aspirin
Versus Ascorbic acid plus Aspirin in Stroke) study. Biofactors. 2005;
24(1-4): 265-74.
38. Black cohosh and St. John's Wort
found effective in alleviating menopausal symptoms.
Uebelhack R, Blohmer JU, et al. Black cohosh and St. John's wort for
climacteric complaints: A randomized trial, Obstetrics
and Gynecology.
2006; 107(2 Part 1): 247-55.
39. Supplementation with carnitine and
DL-alpha lipoic acid improves age-related mitochondrial membrane
damage in rats' hearts.
Savitha S, Panneerselvam C. Mitochondrial membrane damage during aging
process in rat heart: Potential efficacy of l-carnitine and dl alpha
lipoic acid. Mech Ageing Dev. 2006; 127(4): 349-55.
40. Intake of raw garlic lowers glucose, cholesterol, and triglycerides
levels.
Thomson M, Ali M, et al. Including garlic in the diet may help lower
blood glucose, cholesterol, and triglycerides. J
Nutr. 2006; 136(3):
800S-2S.
41. Normalization of levels of reduced glutathione (GSH) ascorbic
acid (AA), superoxide dismutase (SOD), glutathione peroxidase (GPx),
and glutathione reductase (GR) reduces the risk of the oral tumor malignancy.
Fiaschi AI, Cozzolino A, et al. Glutathione, ascorbic acid, and antioxidant
enzymes in the tumor tissue and blood of patients with oral squamous
cell carcinoma. Eur Rev Med Pharmacol Sci. 2005; 9(6): 361-7.
42. Plasma homocysteine levels are inversely related to plasma phospholipid
DHA levels.
Li D, Mann NJ, Sinclair AJ. A significant inverse relationship between
concentrations of plasma homocysteine and phospholipid docosahexaenoic
acid in healthy male subjects. Lipids. 2006; 41(1): 85-9.
43. Lower antioxidant vitamins (A, C, and E) and trace minerals (Zn,
Cu, Mn, Fe, and Se) status found in patients with cerebrovascular disease.
Kwun IS, Park KH, et al. Lower antioxidant vitamins (A, C, and E) and
trace minerals (Zn, Cu, Mn, Fe, and Se) status in patients with cerebrovascular
disease. Nutr Neurosci. 2005; 8(4): 251-7.
44. Propionylcarnitine benefits patients with claudication.
Silvestro A, Schiano V, et al. Effect of propionylcarnitine on changes
in endothelial function and plasma levels of adhesion molecules induced
by acute exercise in patients with intermittent claudication. Angiology.
2006; 57(2): 145-154.
45. Niacin benefits postinfarction patients with and without the metabolic
syndrome.
Canner PL, Furberg CD, et al. Benefits of niacin in patients with versus
without the metabolic syndrome and healed myocardial infarction (from
the Coronary Drug Project). Am J Cardiol. 2006; 97(4): 477-9.
46. Magnesium deficiency is associated with periodontal disease, and
supplementation improves periodontal health.
Meisel P, Schwahn C, et al. Magnesium deficiency is associated with
periodontal disease. J Dent Res. 2005; 84(10): 937-41.
47. Vitamin C prevents vascular dysfunction.
Bohm F, Settergren M, Pernow J. Vitamin C blocks vascular dysfunction
and release of interleukin-6 induced by endothelin-1 in humans in
vivo. Atherosclerosis. 2006 March 7 [Epub ahead of print].
48. Sweet foods high in glycemic index and load increase the risk
of breast cancer.
Tavani A, Giordano L, et al. Consumption of sweet foods and breast
cancer risk in Italy. Ann Oncol. 2006; 17(2): 341-5.
49. Cocoa intakes are inversely associated with blood pressure and
15-year cardiovascular and all-cause mortality.
Buijsse B, Feskens EJ, et al. Cocoa intake, blood pressure, and cardiovascular
mortality: The Zutphen Elderly Study. Arch
Intern Med. 2006; 166(4):
411-7.
50. Diet rich in magnesium reduces the risk of metabolic syndrome.
He K, Liu, K, et al. Magnesium intake and incidence of metabolic syndrome
among young adults. Circulation. 2006, Vol. 113 [Epub ahead of print].
|