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From the Townsend Letter
January 2019

Datapunk Circuits:
A Multi-Dimensional, Open-Source, Genomic Database for Clinical Investigation
by Peter D'Adamo, ND
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PopUp Window Showing Data for Alpha Lipoic Acid
Circuits PopUp Window

Test-Driving Circuits
Readers are encouraged to 'surf' Circuits and explore the target genes that seem more interesting. Click away! However here are a few hard links to help get you started.

TBDNF Essentialshe Code
The server-side portion of Circuits was written in the Perl language, the 'Swiss Army Chainsaw' of bioinformatics. Client-side elements, such as network depictions and graphic displays of information, were coded in JavaScript using the Cytoscape JS and HighCharts JS frameworks. The PPI network was normalized using the Graphviz graphing package and the CPAN Graph module.

The Easter Egg
Users can store particularly interesting or important genes in a non-tracking cookie 'wallet,' for long-term use, thus allowing them to retrace prior investigations.
I hope the Townsend Letter readers have half as much fun exploring Circuits as I did envisioning and coding it. We at the Pathfinder Scholar Program at the COEGM are planning on expanding our open-source offerings to include a microbiota explorer that uses taxon interaction networks and Markov chains to produce a multigenerational approach to eubiosis; and a small metabolite (metabolome) explorer that employs machine learning classifiers to generate metabolic patterning characteristics. I'll make sure to alert the readers when these tools become available.

Circuits: Dataset Linkages
Circuits: Dataset Linkages

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SUPPORTThe Townsend Letter is dedicated to examining and reporting on functional and integrative medicine. Our editorial content depends on support from readers like you, and we would appreciate your help to keep this content forthcoming. Please take this opportunity to contribute $50, or choose one of the other amounts listed on the next page, and ensure that our independent voices keep up the good fight against the skeptics, who would like to silence us and eliminate your medical freedoms.

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8. Wishart DS, et al., HMDB 4.0 — The Human Metabolome Database for 2018. Nucleic Acids Res. 2018. Jan 4;46(D1):D608-17. 29140435

Peter J. D'Adamo, ND
Distinguished Professor of Clinical Medicine and Bioinformatics
Center of Excellence in Generative Medicine
University of Bridgeport, College of Naturopathic Medicine

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