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PopUp Window Showing Data for Alpha Lipoic Acid
Readers are encouraged to 'surf' Circuits and explore the target genes that seem more interesting. Click away! However here are a few hard links to help get you started.
- The ABO 'secretor' gene (FUT2)
- Mitochondrial enzymes that catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin (MAOA and MAOB)
- Catechol-O-methyltransferase (COMT) catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine.
- PPAR-gamma is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis, and cancer.
- MTHFR catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyl-tetra-hydrofolate, a co-substrate for homocysteine (HCy) remethylation to methionine.
The Easter Egg
Users can store particularly interesting or important genes in a non-tracking cookie 'wallet,' for long-term use, thus allowing them to retrace prior investigations.
I hope the Townsend Letter readers have half as much fun exploring Circuits as I did envisioning and coding it. We at the Pathfinder Scholar Program at the COEGM are planning on expanding our open-source offerings to include a microbiota explorer that uses taxon interaction networks and Markov chains to produce a multigenerational approach to eubiosis; and a small metabolite (metabolome) explorer that employs machine learning classifiers to generate metabolic patterning characteristics. I'll make sure to alert the readers when these tools become available.
Circuits: Dataset Linkages
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Peter J. D'Adamo, ND
Distinguished Professor of Clinical Medicine and Bioinformatics
Center of Excellence in Generative Medicine
University of Bridgeport, College of Naturopathic Medicine https://www.coegm.com/