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From the Townsend Letter
June 2013

Rethink Health: Inflammation Is Actually Repair Deficit: Using Physiology First to Achieve Better Outcomes
Part 1: Value and Importance of Understanding Inflammation As Repair Deficit Opportunity
by Russell Jaffe, MD, PhD, CCN, and Jayashree Mani, MS, CCN
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LRA by ELISA/ACT tests are available from:
ELISA/ACT Biotechnologies
109 Carpenter Dr., Suite 100
Sterling, Virginia 20164

Nutritional supplements mentioned in this article are available from:
PERQUE Integrative Health
44621 Guilford Drive, Suite 150
Ashburn, Virginia 20147

For functional biomarker tests:
Better Lab Tests Now
Doctor's Data, Inc.
Shiel Lab

1.  Deuster PA, Jaffe R. A novel treatment for fibromyalgia improves clinical outcomes in a community based study. J Musculo Pain, 1998;6:133–149.
2.  Jaffe R. First-line comprehensive care III: update on immune system lab tests for fibromyalgia-chronic fatigue-metabolic syndrome: continuum of treatment-resistant pain and fatigue: optimum clinical management improves outcomes and reduces risks and treatment complications as supported by new data. Townsend Lett. 2008;Jan:87–94.
3.  Jaffe R, Mani J, DeVane J, Mani H. Tolerance loss in diabetics: association with foreign antigen exposure. Diabet Med. 2006;23(8):924–925.
4.  Jaffe R. Quercetin & OPC: nature's solution to inflammation [webinar].
5.  Health Studies Collegium. The Joy of Food: The Alkaline Way Guide. 18th ed. 1992–2010.
6.  Holmes C, Cunningham C, Zotova E, Culliford D, Perry VH. Proinflammatory cytokines, sickness behavior, and Alzheimer disease. Neurology,2012;77(3):212–218.
7.  Schmidt MI, Duncan BB. Diabesity: an inflammatory metabolic condition (review). Clin Chem Lab Med. 2003 Sep;41(9):1120–1130.
8.  Ballantyne CM,  Hoogeveen RC, Bang H, et al. Lipoprotein-associated phospholipase a2, high-sensitivity c-reactive protein, and risk for incident coronary heart disease in middle-aged men and women in the Atherosclerosis Risk in Communities (ARIC) study. Circulation. 2004;109:837–842 .
9.  Nygård O, Nordrehaug JE, Refsum H, Ueland PM, Farstad M, Vollset SE. Plasma homocysteine levels and mortality in patients with coronary artery disease. N Engl J Med. 1997 Jul 24;337(4):230–236.
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22.Crisp HC, Quinn JM. Quantitative immunoglobulins in adulthood. Allergy Asthma Proc. 2009;30(6):649–654.
23. Lux A, Aschermann S, Biburger M, Nimmerjahn F. The pro and anti-inflammatory activities of immunoglobulin G. Ann Rheum Dis. 2010;69 Suppl 1:i92–96.
24. Woof JM, Mestecky J. Mucosal immunoglobulins – review. Immunol Rev. 2005:64–82.
25. Woof JM, Kerr MA. The function of immunoglobulin A in immunity. J Pathol. 2007;208(2):270–282.
26. Laevy O. Unmasking IgG responses. Nat Rev Immunol. 2006;6:632.  
27. Hodsdon, W., Zwickey, H. Reproducibility and reliability of two food allergy testing methods. Nat Med J. 2010;2(3):8–13.
28. Jaffe R. Improved immune function using specific nutrient supplementation and ELISA/ACT "immunologic fingerprint" to detect late phase responses ex vivo. J Am Coll Nutr.1989;8(5):424.
29.Deuster PA, Jaffe R. A novel treatment for fibromyalgia improves clinical outcomes in a community based study. J Musculo Pain. 1998;6:133–149; Jaffe R, Mani J, DeVane J, Mani H. Tolerance loss in diabetics: Association with foreign antigen exposure. Diabet Med. 2006;23(8):924–925.
30.ELISA/ACT Biotechnologies Newsletter. 2010;1(2). Available at
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Dr. Russell JaffeDr. Russell Jaffe received his AB, MD (with senior thesis honors), and PhD (In biochemistry and physiology) from Boston University. Dr. Jaffe served his medical internship at University Hospital and was awarded a the US Public Health Service Officer Commission, assigned to the Clinical Center of the National Institutes of Health, in June 1973. While at the Clinical Center, Dr. Jaffe served his residency in clinical pathology. He is board certified in clinical and subspecialty certified in chemical pathology. Dr. Jaffe remained on the permanent senior staff of the NIH Clinical Pathology Department, where he continued method innovation and was active in collaborative research with the Laboratory of Experimental Atherosclerosis (of the Heart, Lung, and Blood Institute). Concurrently, Dr. Jaffe's interests in the mechanisms of health and the evoking of human healing responses led him to apprentice in such healing arts as acupuncture; mindfulness; massage; music, art, and color therapy; and a variety of eclectic therapeutic approaches. In addition, Dr. Jaffe performed innovative studies of platelet function and blood clotting in relation to the origins of coronary artery and cardiovascular diseases. Among the tests that he developed are the early colon cancer-screening test using occult blood detection not interfered with by vitamin C consumption, as well as a variety of tests related to the blood clotting and immune defense and repair systems. Dr. Jaffe developed the first method of measuring cell-mediated immunity using a modified ELISA system in a lymphocyte mitogenesis/blastogenesis brief cell culture known as lymphocyte response assays (LRA). This LRA by ELISA/ACT provides an "immunologic fingerprint" of items to which the body is reactive or tolerant. Dr. Jaffe has contributed over 100 symposium-invited talks, scientific articles, or book chapters. He received the J. D. Lane award for original research from the USPHS, the Merck Sharp and Dohme Excellence in Research Award, and in 2002 the International Research Scientist of the Year, among other recognitions for his investigations. Dr. Jaffe is a fellow of the Health Studies Collegium and director of ELISA/ACT Biotechnologies LLC and PERQUE LLC in Ashburn, Virginia. He may be reached at 800-525-7372 ext. 5101, and or

Jayashree ManiJayashree Mani, MS, CCN is a clinical nutritionist with over 20 years' experience in providing nutritional counseling and education to patients and physicians in various medical environments. Her focus over the past 10 years has been on the functional use of lymphocyte cell response assays in clinical management of various autoimmune conditions, including fibromyalgia, chronic fatigue syndrome, and irritable bowel syndrome. Developing nutritional protocols involving the Alkaline Way and specific nutritional supplementation, her work also includes specific emphasis on diabetes and metabolic syndrome and its management. She has coauthored chapters on these topics and published scientific articles describing these comprehensive approaches as well. She may be contacted at PERQUE Integrative Health/ELISA/ACT Biotechnologies; 800-525-7372 or 703-840-4427; or

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