Part
1 appeared
in October 2007
Part 3 December 2007
Page 1, 2, Notes
In
Part 1 of this series, we discussed the
reasons why we should challenge the assumption that vaccines are
safe and effective. These reasons include
the adverse effects associated with vaccines, the unsound principles on
which they are based, questions about whether vaccinations have really
eliminated
disease, the toxic ingredients used in vaccines, and vaccine failures and
waning immunity. In Part 2, we look at the effects of specific vaccines,
including those for diphtheria, pertussis, tetanus, polio, chickenpox,
hepatitis B, measles, mumps and rubella.
DIPHTHERIA, TETANUS AND PERTUSSIS
VACCINE
Diphtheria Toxoid
According to the Centers for Disease Control and Prevention (CDC),
the incidence of diphtheria was reduced to zero by 2004, from an
estimated average of 21,053 cases per year in the 20th century.1
But as with
other infectious diseases, much of the decline in mortality from
diphtheria had occurred before the vaccine was used. This mortality
rate fell
from 40 deaths per 100,000 in 1900 to approximately 16 per 100,000
in 1920, when the diphtheria vaccine was introduced in the US.2
Pertussis Vaccine
Despite high levels of childhood vaccination coverage for pertussis
(whooping cough), the largest outbreak of this disease in four decades
has occurred in recent years. There were 25,827 reported cases of
pertussis in 2004 (the actual incidence could be higher due to underreporting),
compared with a low of 1,010 in 1976.3
According to the CDC, the reported rate of pertussis per 100,000 population
increased from 1.8 in 1994 to 8.9 in 2004. The 2004 rate was the third
consecutive annual increase in the incidence of pertussis. The CDC
notes that two-thirds of reported cases of pertussis now occur among
adolescents and adults due to the waning of vaccine-induced immunity.
This waning occurs five to ten years after receipt of the vaccine.
4
Similar trends in pertussis were noted nearly 20 years ago in a 1988
report. After the US mandated whooping cough vaccination in 1978, the
incidence of the disease in the next eight years trebled. The highest
incidence was in infants less than one year old. However, the highest
relative increase was in adolescents and adults.5
In 2006, the CDC's Advisory Committee on Immunization Practices
(ACIP) addressed the rise of whooping cough among adolescents by recommending
that they receive another dose of pertussis vaccine. The Tdap vaccine
(which also contains tetanus and diphtheria toxoids) is now recommended
for all children age 11 to 18 and replaces the tetanus-diphtheria booster
previously given to adolescents. The Tdap booster adds to the five
doses of diphtheria, pertussis, and tetanus that children already receive
before their seventh birthday.6
Several research papers suggest that immunization programs have not
yet brought pertussis under control. A 2006 article reports that pertussis "has
reemerged worldwide as a cause of substantial morbidity and mortality
in infants, children, and adolescents, despite high vaccination rates."7
Another report, published in 2005, states that an increased incidence
of pertussis "has been observed worldwide since the introduction
of widespread vaccination." These researchers say that there
has been "a general shift in the age distribution of pertussis
toward older groups" and that "despite high coverage rates
for primary immunization in infants and children, pertussis continues
to be a global concern, with increased incidence widely noted."8
On the other hand, the merit of the pertussis vaccine is indicated
by a 2006 paper. This research evaluated state-level rates of nonmedical
exemptions (those based on religious or personal beliefs) to mandatory
vaccination from 1991 to 2004 and the incidence of pertussis among
people 18 and younger from 1986 to 2004. The study found that an increased
incidence of pertussis was associated with state policies granting
personal-belief exemptions and the easier granting of exemptions.9
Replacement of the whole cell pertussis vaccine. The US made a major
vaccine substitution in the 1990s when it replaced the diphtheria,
tetanus, and whole cell pertussis vaccine (DTP) with a diphtheria,
tetanus, and acellular pertussis vaccine (DTaP).10 The whole cell vaccine
has been associated with serious adverse reactions (such as seizures
and encephalopathy).11
Studies have since found a decline in the number of adverse reactions
to pertussis-containing vaccines. An analysis of reports made to the
Vaccine Adverse Event Reporting System (VAERS) from 1991 to 2001 found
that the overall reporting rate decreased substantially after use of
the acellular petussis vaccine compared with the whole cell version
(12.5 vs. 26.2 reports per 100,000 net doses distributed).12
An analysis of VAERS data from 1995 (when the whole cell vaccine was
in use) to 1998 (when the acellular vaccine was predominant) found
that the number of reports concerning pertussis fell from 2071 in 1995
to 491 in the first half of 1998. Events categorized as "nonfatal
serious" fell from 334 in 1995 to 93 (first-half '98).
However, the decrease in reports involving deaths was modest, from
85 deaths in 1995 to 77 in 1997 and 41 in the first half of 1998.13
Recent comparisons of the whole cell and acellular pertussis vaccines
confirm that the older version caused more adverse reactions. One study
of VAERS evaluated the number of emergency room visits, life-threatening
reactions, hospitalizations, disabilities, deaths, seizures, infantile
spasms, encephalitis/encephalopathy, autism, sudden infant death syndrome
(SIDS), and speech disorders that began within three days of receipt
of pertussis-containing vaccines. The study found statistical increases
for all of these events, except cerebellar ataxia, following whole
cell vaccination compared with acellular vaccination.14 In Japan, an
analysis of two decades of use of the acellular vaccine showed that
while neurological illnesses were rare with both types of pertussis
vaccine, the incidences of encephalopathy/encephalitis and status epileptics/frequent
convulsions, febrile seizures/provocation of convulsions, and sudden
deaths were significantly lower with the acellular than the whole cell
vaccine.15 A study in Canada reported a 79% decrease in febrile seizures
and a 60% to 67% decrease in hypotonic-hyporesponsive episodes following
the introduction of the acellular vaccine there.16
Other research has associated the whole cell vaccine with neurological
complications, including convulsions, hypotonic-hyporesponsive episodes,
paralysis, and encephalopathy.17,18,19,20,21,22 Sadly, the DTP
vaccine also has been associated with SIDS, the unexpected death of
an infant for which autopsy cannot reveal a determining cause. In 1982
William Torch reported that his investigation of 70 SIDS cases (which
was triggered by a report of 12 such deaths occurring within three-and-one-half
hours to 19 hours of DPT vaccination) found that two-thirds of the
victims had been vaccinated from a half-day to three weeks prior to
death.23
Torch reaffirmed a link between DTP and SIDS in 1986, when he presented
11 new cases of SIDS and one of near-miss syndrome occurring within
24 hours of DTP injection24 Analysis of these and more than 150 cases
of DTP post-vaccinal deaths reported in the literature—about
half of which were sudden or anaphylactic—led Torch to conclude: "Although
many feel that the DPT-SIDS relationship is temporal, this author and
others maintain a casual relationship exists in a yet-to-be-determined
SIDS fraction."25
Other researchers also have uncovered a relationship between DTP and
SIDS.26,27 However, the CDC reported in 199628 that several studies
conducted in the 1980s did not find an association between DTP vaccination
and SIDS.29,30
Pertussis vaccination and asthma. A 1994 study found that children
immunized against whooping cough were five times more likely to suffer
from asthma than those who did not receive the vaccine.31 Another study
of almost 2,000 children born between 1974 and 1984 showed that vaccination
against whooping cough was associated with a 76% increased risk of
developing asthma and other allergic diseases later in life.32 On the
other hand, a study published by the CDC of more than 160,000 children
did not find an association between the DTP vaccine and the risk of
asthma.33 A 2006 report from the Netherlands also found that receipt
of the DTP/polio vaccine in infancy was not related to reported atopic
disorders at primary school age.34
Tetanus Toxoid
The literature includes articles on neurological reactions to the tetanus
vaccination35-40 and other adverse reactions.41-43
POLIO
VACCINE
Three types of polio vaccines have been
used throughout the world: 1) the OPV, or oral polio vaccine (Sabin
vaccine), consisting
of
live attenuated poliovirus; 2) the IPV, or inactivated polio
vaccine (Salk
vaccine), consisting of killed poliovirus and given by injection;
and 3) the eIPV, an enhanced potency inactivated polio vaccine,
consisting of killed poliovirus with high viral antigen content.
In the United States, the IPV (enhanced potency version) has been
recommended for routine childhood vaccination against polio since
2000. Before
that, the live attenuated OPV was the polio vaccine of choice
for more than three decades. This vaccine, however, actually caused
polio—vaccine-associated
paralytic poliomyelitis (VAPP)—in a small percentage of
recipients.44
The risk of VAPP "became more difficult to justify" as
polio was controlled worldwide and importations of wild poliovirus
to the US became less likely, according to an article in the Journal
of the American Medical Association.45
As a result,
in 1996 the government recommended a sequential schedule using
both IPV and OPV for the childhood polio vaccination
series.
The ACIP then recommended the all-IPV schedule in 2000.
According to the CDC, the overall risk for VAPP is approximately
one case in 2.4 million OPV doses distributed, while the first-dose
risk
is one case in 750,000 doses distributed. The OPV has caused
the only indigenous cases of polio reported in the US since 1979.
Between
1980
and 1998, 144 cases of VAPP were reported.46 Another VAPP case
occurred in 1999, and in 2005, a case of imported VAPP was reported
in the
US after an unvaccinated American woman traveled to Central America
and
was exposed to an infant vaccinated with OPV.47 In late 2005,
four cases of vaccine-derived poliovirus (VDPV) involving a poliovirus
strain used in the OPV were identified in unvaccinated children
in
an Amish
community in Minnesota. The source of these infections is not
known, since the OPV has not been used in the US since 2000.48
During the time that the trivalent OPV was used in the US (from
1963 to 1999), an inactivated polio vaccine was available. The
original
IPV, developed by Jonas Salk, was used to immunize American children
from 1955 to 1962. According to the JAMA article, the OPV became
preferred to the IPV because it provided better intestinal immunity,
was able
to indirectly vaccinate susceptible contacts through transmission
of vaccine polioviruses, was easier to administer, and cost less.49
Although IPV does not cause VAPP, the severity profiles of
reports to VAERS on IPV and OPV in infants up to six months
of age were "remarkably
similar." Among the most frequent symptoms reported for
IPV were fever, SIDS, convulsions, agitation, apnea, and stupor.
Reports
of
fatalities in 1998 per 100,000 doses distributed were somewhat
higher for IPV than for OPV. Of 142 fatalities reported for
both IPV and OPV
in 1997-1998, 89 indicated SIDS.50
Polio vaccine and Guillain-Barre syndrome. GBS is a disease that
involves the nervous system and is characterized by muscle weakness,
numbness,
loss of reflexes, and paralysis.
In Finland, in 1985, there was an increase in the incidence of
GBS a few weeks after the implementation of a nationwide campaign
using
OPV.51,52 And in Brazil, an analysis of 38 cases of paralysis
diagnosed as GBS led in all cases to the isolation of the vaccine
strains of
the poliovirus. All patients had been vaccinated with the OPV
months or years before the onset of symptoms.53 In contrast,
two other studies
failed to find a correlation between GBS and the OPV.54,55
Vaccine viruses also have been isolated from patients with paralysis
diagnosed as transverse myelitis (TM), and in patients with facial
paralysis (FP).56 Most individuals with TM and FP had received
the OPV months or years prior to the onset of disease, indicating
that
the virus may remain latent and revert to virulence later in
time.
Polio vaccine and SV40-related cancers. Research conducted in
the past few decades has revealed that several types of cancer
may be
associated
with the receipt of polio vaccines more than 40 years ago that
were contaminated with a monkey virus.
In 1960, it was discovered that the Salk IPV was contaminated
with SV40 (simian virus 40), which was derived from the monkey
cells used
to grow the vaccine
viruses. The SV40 survived inactivation with formaldehyde, the method
used to kill the poliovirus for use in the vaccine. More than
98 million Americans
were vaccinated during the time period (from 1955 to 1963)57 that injectable
and oral doses of the polio vaccine were contaminated with SV40. These
people today have SV40 sequences integrated into their genetic
code.
Animal studies have demonstrated the ability of SV40 to integrate its
DNA into that of the host cell and induce malignancy. Unfortunately,
studies
show that
the virus retains these same properties in humans and is associated
with increased rates of certain cancers.58 Integration and replication
of
SV40 has been documented
in 13% to 43% of non-Hodgkin's lymphomas,59,60 47% to 83%
of mesotheliomas (malignant tumors of the lining of the lungs),61,62 11%
to 90% of different types of brain tumors,63-66 50%
of osteosarcomas,67 more than
33% of other types of bone tumors,68,69 and 28% of bronchopulmonary
carcinomas.70
A continuing concern is that SV40 may be transmitted from person to person.
The virus has been detected in people born in the 1980s and 1990s, decades
after the tainted polio vaccine was no longer in use.71 SV40 is now present
in children, as noted by Kurt Link, MD, in his 2005 book The
Vaccine Controversy, and the CDC takes this as evidence that
SV40 is a naturally acquired infection
unrelated to exposure to the contaminated polio vaccine. But as Dr.
Link states, it is more likely that people infected by the vaccine
have transmitted
SV40
to others or to their offspring (such as through semen). The implication,
he says, is that "any SV40 problems may not, as had been hoped,
fade away with time. There is even now, ironically, work being done
to provide a vaccine
against SV40."72
It should be noted that other research indicates there is no association
between SV40 and an increased risk of rare cancers such as ependymomas,
osteosarcomas, and mesotheliomas. One study compared rates of cancer
after 30 years in birth
cohorts who were likely to have received SV40-contaminated vaccine as
infants and children with rates in people who not unexposed. Age-specific
cancer
rates
were not significantly elevated for those exposed to the tainted vaccine.73
Another study found no increased number of cancer deaths among 1,073
people who received SV40-contaminated vaccine,74 and a 35-year follow-up
found no
deaths from the types of tumors that have been linked to SV40.75
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