Continued.
. . 1, 2, 3, 4, 5, 6, 7, 8, 9,
10, 11, 12
Chart 12: Methods/Assessment
Assessment of clinical outcome was based on the pain response of the
patients, divided into four groups.
Group I – Excellent, positive
outcome, patients whose pain was reduced 75% in 72 hours and may
require minor over-the-counter pain
medication.
Group II – Good, positive outcome, patients whose pain was
reduced 75% within seven days and who may require minor pain control
(aspirin).
Group III – Fair, positive outcome,
patients with 50% reduction in pain, requiring a second procedure
within 14 days.
Group IV – Poor, negative outcome,
patients with less than 50% reduction in pain after 14 days and with
a second antimicrobial protocol.
Chart 13: Outcome from Open Clinical Study
The overall outcome results – 42
patients:
Group I – positive outcome,
excellent, ten patients, 23.8%. Group II – positive outcome,
good, 26 patients, 61.9%.
Group III – fair outcome, four
patients, 9.5%.
Group IV – poor outcome, two
patients, 4.8%.
Total positive response 95.23%.
Figure
12 (12KB .pdf) shows the above results
in graph form.
DETECTION OF FUNGUS FROM BLOOD SAMPLES
Non-culture methods now being developed
and evaluated for mycotic infections include High Resolution Blood
Morphology (HRBM™), polymerase
chain reaction (PCR), galactomannan antigenemia, Western blot to detect
antibodies, and other methods to detect the fungal metabolites D-arabinitol
and (1,3)-beta-D-glucan. Sample preparation for PCR from blood specimens
depends on fractionation of peripheral blood, its pre-incubation in
blood culture broth, or a total DNA method that does not rely on fractionation
or pre-incubation. A pilot study indicated that PCR tests on blood
specimens were positive at least once in patients with confirmed invasive
aspergillosis. Produced by most general of pathogenic fungi, (1,3)-beta-D-glucan
can be detected in plasma by the "G-test."106 High Resolution
Microscopy, PCR, and the G-test are the most reliable. Antibody detection
is the least reliable, giving significantly false, negative results.77,123
The PCR method was capable of detecting a wide range of medically
important fungi from clinical specimens. The test is based on the detection
of certain ribosomal RNA genes shared by most fungi. The lower limit
of detection was 1 pg (picogram) of Candida albicans genomic DNA. A
687-bp (base-pair) product was amplified successfully by PCR from all
78 strains of 25 medically important fungal species, including Candida,
Hansenula, Saccharomyces cerevisiae, Cryptococcus neoformans, Trichosporon
beigelii, Malassezia furfur, Pneumosystis carinii, Aspergillus sp.,
and Penicillium sp. Detection by PCR of fungus in clinical samples
including blood, cerebrospinal fluid, and sputum appeared to be a more
sensitive diagnostic method for fungal infections than a conventional
blood culture technique.107
In a two-year study, 121 patients admitted to the University Hospital
of Innsbruck, Germany, for cancer chemotherapy, without clinical signs
of fungal infection, were screened for Aspergillus. In 23% of these
patients, Aspergillus was detected by the PCR method. Positive PCR
results became negative shortly after antifungal treatment was begun.108
Diagnosing the invasion of deep organs by Candida has been difficult
for two reasons. First, patients may have extensive Candida infections
of several deep organs, yet have negative blood cultures. Second, the
meaning of a positive blood culture for Candida has been questioned,
especially during the early years of the organism's emergence as a
pathogen. There is a crucial need for an accurate, cost-effective test
more sensitive than blood cultures for diagnosing Candida infections
of deep organs. Inevitably, however, invasive candidiasis will develop
in some patients who will die before they test positive.131 This demonstrates
that the blood culture test alone is both unreliable and insensitive.
THERAPY Broad-Base Antimicrobial Infusion
The broad-spectrum, anti-microbial protocol developed by the Bradford
Research Institute is presented. This ongoing, investigative protocol
consists of three sequential intravenous infusions designed for anti-microbial,
anti-oxidant, immune-stimulating, and anti-inflammatory properties.
This protocol should be considered for individuals with symptoms
associated with systemic microbial overload, including fungal, bacterial,
viral, and mycoplasmal. Benadryl, as an antihistamine, was administered
to minimize the microbial die-off reactions. The pain of fibromyalgia
patients is greatly diminished in a majority of patients within 12
hours of administration.
Aerobic Exercise
A controlled clinical study included
27 fibromyalgia patients (25 female, two male) who performed 12 weeks
of jogging, walking, cycling, or
swimming following a given schedule. Twelve sedentary fibromyalgia
patients (11 female, one male) served as controls. Patients trained
for an average of 25 minutes, two to three times a week. Pain parameters
remained unchanged in the control group, but in the training group,
the mean number of positive tender points, the mean pain threshold
of the gluteal tender point, and the painful body condition deteriorated
in only two patients but improved in 17. These results suggest a
positive effect of aerobic endurance on fitness and well-being in
fibromyalgia patients.29 It has been demonstrated, using American
Biologics' chemoluminescence Redox Probe that exercise is an
efficient method to oxidize the blood.124
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