Aristo Vojdani PhD, MSc
Aristo Vojdani is presently a professor of neuroimmunology at the Carrick Institute for Graduate Studies and past associate professor at the UCLA School of Medicine and Science. He obtained his MSc and PhD in the field of microbiology and clinical immunology with postdoctoral studies in tumor immunology at UCLA. His ongoing research, spanning a 45-year career, focuses on the role of environmental factors in complex diseases. Dr. Vojdani's research on predictive antibodies has resulted in the development of numerous antibody arrays for the detection of autoimmune disorders. He is the CEO and technical director of Immunosciences Lab in Los Angeles and chief scientific advisor for Cyrex Labs in Phoenix. Owner of 15 US patents for laboratory assessments, Dr. Vojdani has published more than 140 scientific articles and sits on the editorial boards of six scientific journals. He is recipient of the Herbert J. Rinkel Award (2006) from the American Academy of Environmental Medicine, the Linus Pauling Award (2009) from the American College for Advancement in Medicine, and the Carrick Research Institute's Lifetime Achievement Award (2012).
Cyrex™ Labs is an advanced clinical laboratory focusing on mucosal, cellular, and humoral immunology. Cyrex specializes in antibody arrays for the early detection and monitoring of complex conditions such as thyroid disorders, as well as gluten reactivity and other food-associated autoimmunities, and related neurodysregulation. Cyrex's scientific advisory board, comprised of experts from a variety of medical and research disciplines, brings together the latest findings from medical research and the assessment needs of today's healthcare professionals for the development of innovative arrays. For additional information, see www.CyrexLabs.com.
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NEW JOURNAL: Brain and Gut
Mary Ann Liebert, Inc., publisher, announces the launch of a new peer-reviewed journal, Brain and Gut, launching summer 2014.David Perlmutter, MD, a board-certified neurologist, will serve as Editor-in-Chief. Aristo Vojdani, PhD, Director of Immunosciences Lab, Inc., Los Angeles, California, and Gerard E. Mullin, MD, Associate Professor of Medicine, Johns Hopkins University School of Medicine, will both serve as Editors.The journal will publish leading-edge research with a whole systems approach to digestive disorders, cognitive issues, mood disorders, autoimmune conditions, diabetes, and cancer, encompassing the intersection of neurology, gastroenterology, and immunology.
This article is drawn from the writing of Aristo Vojdani, PhD, and also includes interview content. The editor, Nancy Faass, MSW, MPH, provides support for authors in the development of articles, books, manuals, white papers, and writing for the Web via her company, HealthWritersGroup.com
Our thanks to Jerry Stine, NC, for technical support on this article; see www.Lifespan-Institute.com.
Diamond B, Honig G, Mader S, Brimberg L, Volpe BT. Brain-reactive antibodies and diseases. Annu Rev Immunol, 31: 345-385, 2013.
Diamond B, Huerta PT, Mina-Osorio P, Kowal C, Volpe BT. Losing your nerves? Maybe it's the antibodies. Nat Rev Immunol, 9:449-456, 2009.
Dietrich JB. Alteration of blood-brain barrier function by methamphetamine and cocaine. Cell Tissue Res, 336:385-392, 2009.
Frey AH. Headaches from cellular telephones: are they real and what are the implications? Environ Health Perspect. 106(3):101-3, Mar 1998.
Friedman A, Kaufer D, Shemer J, Hendler I, Soreq H, Tur-Kaspa I. Pyridostigmine brain penetration under stress enhances neuronal excitability and induces early immediate transcriptional response. Nat Med, 2: 1382-1385, 1996.
Hanin I. The Gulf war, stress, and a leaky blood-brain barrier. Nat Med, 2(12):1307-1308, 1996.
Hazleton JE, Berman JW, Eugenin EA. Novel mechanism of central nervous system damage in HIV infection. HIV/AIDS Res Palliat Care, 2:39-49, 2010.
Marchi N, Bazarian JJ, Puvenna V, Janigro M, Ghosh C, Zhong J, Zhu T, Blackam E, Stewart D, Ellis J, Butler R, Janigro D. Consequences of repeated blood-brain barrier disruption in football players. PLoS One, 8(3):e56805, 2013.
Maroon JC, Lepere DB, Blaylock RL, Bost JW. Postconcussion syndrome: a review of pathophysiology and potential nonpharmacological approaches to treatment. Phys Sportsmed, 40:73-87, 2012
Nittby H, Brun A, Eberhardt J, Malmgren L, Persson BR, Salford LG. Increased blood-brain barrier permeability in mammalian brain 7 days after exposure to the radiation from a GSM-900 mobile phone. Pathophysiology. 16(2-3):103-12, Aug 2009, Epub Apr 2009.
Perlmutter D, Vojdani A. Association between headache and sensitivities to gluten and dairy. Integrative Medicine, 12(2):39-44, 2013.
Salford LG, Brun A, Sturesson K, Eberhardt JL, Persson BR. Permeability of the blood-brain barrier induced by 915 MHz electromagnetic radiation, continuous wave and modulated at 8, 16, 50, and 200 Hz. Microsc Res Tech. 15;27(6):535-42, Apr 1994.
Seelbach M. Polychlorinated bishpenyls disrupt blood-brain barrier integrity and promote brain metastases formation. Env Health Persp, 118:479-484, 2010.
Vojdani A. A potential link between environmental triggers and autoimmunity. Autoimmune Disease, Volume 2014, Article ID 437231, 18 pages. http://dx.doi.org/10.1155/2014/437231, 2014.
Vojdani A. Antibodies as predictors of autoimmune diseases and cancer. Expert Opinion on Medical Diagnostics; 2(6):593-605, 2008.
Vojdani A. Brain-reactive antibodies in traumatic brain injury. Functional Neurology, Rehabilitation, and Ergonomics, 3(2-3):173-181, 2013.
Vojdani A. Celiac disease and its association with other autoimmune disorders beyond the gut. Townsend Letter, June 2013.
Vojdani A. Detection of IgE, IgG, IgA and IgM antibodies against raw and processed food antigens. Nutrition and Metabolism; 6:(22), 2009.
Vojdani A. For the assessment of intestinal permeability, size matters. Alternative Therapies in Health and Medicine, 19(1):12-24, 2013.
Vojdani A. The characterization of the repertoire of wheat antigens and peptides involved in the humoral immune responses in patients with gluten sensitivity and Crohn's disease. ISRN Allergy; 2011, doi:10.5402/2011/950104, 1-12.
Vojdani A, Bautista J. Intestinal and blood-brain barrier: Interface between health and diseases. Functional Neurology, Rehabilitation, and Ergonomics, 2(3): 277-297, 2012.
Vojdani A., Campbell A., Anyanwu E., Kashanian A., Bock K., Vojdani E., Antibodies to neuron-specific antigens in children with autism: possible cross-reaction with encephalitogenic proteins from milk, Chlamydia pneumoniae and Streptococcus Group A. J. Neuroimmunol. 129:168-177, 2002.
Vojdani A, Kharrazian D, Mukherjee PS. Elevated levels of antibodies against xenobiotics in a subgroup of healthy subjects. Journal of Applied Toxicology, (In Press), 2014.
Vojdani A, Kharrazian D, Mukherjee PS. The prevalence of antibodies against wheat and milk proteins in blood donors and their contribution to neuroautoimune reactivities. Nutrients, 6:15-36, 2014, doi:10.3390/nu6010015.
Vojdani A, Lambert J. Functional neurology and immunology: V. Crossing barriers: gut-to-brain lessons from interdisciplinary collaboration. Functional Neurology, Rehabilitation, and Ergonomics, 1(4): 615-630, 2011.
Vojdani A., O'Bryan T., Green J.A., McCandless J., Woeller K.N., Vojdani E., Nourian A.A., Cooper E.L. Immune response to dietary proteins, gliadin and cerebellar peptides in children with autism. Nutritional Neuroscience 7(3):151-161, June 2004.
Vojdani A, Perlmutter D. Differentiation between celiac disease, non-celiac gluten sensitivity, and their overlapping with Crohn's disease: a case series. Case Reports in Immunology, 2013, dx.doi.org/10.1155/2013/248482.
Vojdani A, Tarash I. Cross-reaction between gliadin and different food and tissue antigens. Food and Nutrition Sciences, 44:20-32, 2013.
Vojdani A., Thrasher J.D., Cellular and humoral immune abnormalities in Gulf War veterans. Environmental Health Perspectives 112(8):840-846, June 2004.
Vojdani A., Vojdani E., Cooper E.L., Antibodies to myelin basic protein, myelin oligodendrocytes peptides, a-b-crystallin, lymphocyte activation and cytokine production in patients with multiple sclerosis. J. Internal Med. 254:363-374, 2003.
Xaio H, Banks WA, Niehoff ML, Morley JE. Effect of LPS on the permeability of the blood-brain barrier to insulin. Brain Res, 896:36-42, 2001.
Zheng W, Aschner M, Ghersi-Egea JF. Brain barrier systems: a new frontier in metal neurotoxicological research. Tox App Pharmacol, 192:1-11, 2003.
Zlokovic BV. The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron, 57: 178-201, 2008.
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