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From the Townsend Letter
October 2015

Nrf2 Is a Master Regulator of Cytoprotective Responses Including Antioxidant, Anti-Inflammatory, Detoxification, Improved Mitochondrial Function, and Autophagy
by Martin L. Pall, PhD, and Stephen Levine, PhD
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51.    Schäfer M, Willrodt AH, et al. Activation of Nrf2 in keratinocytes causes chloracne (MADISH)-like skin disease in mice. EMBO Mol Med. 2014;6:442–457.
52.    Tan NS, Wahli W. The emerging role of Nrf2 in dermatotoxicology. EMBO Mol Med. 2014;6:431–433.
53.    Wakabayashi N, Itoh K, et al. Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation. Nat Genet. 2003;35:238–245.
54.    Pall ML. Explaining "Unexplained Illness": Disease Paradigm for Chronic Fatigue Syndrome, Multiple Chemical Sensitivity, Fibromyalgia, Post-Traumatic Stress Disorder, Gulf War Syndrome and Others. New York: Harrington Park (Haworth) Press; 2007.
55.    Pall ML. Teufelskreis NO/ONOO--Zyklus, oxidaver Stress, mitochondriale, inflammatorische und neurologische Dysfunktion. Umwelt Medizin Gesellshaft. 2010;23:281–293.
56.    Pall ML. The NO/ONOO- cycle as the central cause of heart failure. Int J Mol Sci. 2013;14:22274–22330.
57.    Pall ML. Is open-angle glaucoma caused by the NO/ONOO(-) cycle acting at two locations in the eye? Med Hypothesis Discov Innov Ophthalmol. 2014;4:1–2.
58.    Pall ML, Levine S. Nrf2, a master regulator of detoxification and also antioxidant, anti-inflammatory and other cytoprotective mechanisms, is raised by health promoting factors. Acta Physiologica Sinica. 2015;67:1–18.

Martin L. Pall, PhD, Professor Emeritus of Biochemistry and Basic Medical Sciences, Washington State University

638 NE 41st Ave.
Portland, Oregon 97232-3312

Stephen Levine, PhD, founder and former CEO of the Allergy Research Group.

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