Testosterone Confound: When PSA Velocity Tells the Wrong Story
By Geo Espinosa – A PSA that climbs fivefold in eight months usually means you missed something. Sometimes it means the patient forgot to mention his testosterone injections.
By Geo Espinosa – A PSA that climbs fivefold in eight months usually means you missed something. Sometimes it means the patient forgot to mention his testosterone injections.
By Geo Espinosa, ND – Mortality has several doors: prostate cancer, cardiovascular disease, other cancers, and other causes. When the investigators tracked which door men went through, the excess deaths tied to saturated fat went mostly through the cardiovascular door.
By Geo Espinosa – For prevention-oriented men, the defensible recommendation is dietary: three or more mushroom meals per week across varied species. Shiitake, oyster, maitake, and king oyster are the antioxidant-dense choices. The nutritional upside is real — high fiber, low glycemic index, very low fat, protein content in some species rivaling animal sources.
By Geo Espinosa – The integrative goal is to remodel the metabolic environment that drives erectile failure in the first place. That means restoring endothelial function, preserving lean mass, supporting endogenous testosterone, normalizing inflammation, and rebuilding the autonomic balance that allows arousal to translate into a usable erection.
Weight loss is the lever. Sexual function is one of the most honest readouts of whether the lever worked.
By Geo Espinosa – In integrative medicine, we’ve always understood that a treatment your patient can’t tolerate isn’t actually treating anything. Quality of life is not a soft endpoint. It’s time to add transdermal estradiol to our fluent vocabulary of ADT options — not as a fringe alternative, but as a legitimate, evidence-supported choice.
By Shayesteh Manesh, ND – As microbiome research advances toward functional and interventional models, studies will help shape a more nuanced and systems-based understanding of prostate disease.
By Geo Espinosa, ND, LAc – Current diagnostic tools, such as PSA, mostly predict biopsy positivity or the presence of clinically significant cancer, but do not show the actual risk of dying from prostate cancer, how life expectancy and comorbid disease modify that risk, or whether there is any meaningful benefit to continued screening.
By Geo Espinosa – Melatonin is neither the benign panacea patients assume nor the cardiotoxic agent suggested by headlines. Its value lies in circadian stabilization, vascular support, REM enhancement, and antioxidant function—when used correctly, at the right time, and under clinical guidance.
By Geo Espinosa, ND, LAc – Two decades ago, localized prostate cancer care mostly meant an open prostatectomy or ~40 fractions of pelvic radiation.
Today, the menu is far broader—robot-assisted techniques that prioritize functional preservation, ultra-hypofractionated radiation that may be delivered in as few as 2 fractions in select protocols, and ≥5 focal therapy modalities that target the index lesion while sparing the uninvolved gland.
The challenge isn’t a lack of options—it’s matching the right patient to the right intensity at the right time.
By Geo Espinosa, ND, LAc – PSA is our main blood test for prostate cancer. But in men with hypogonadism (low testosterone), PSA can look deceptively low—even when high-grade cancer is present, and this can delay diagnosis and treatment at the very early stages, when catching cancer matters the most.
By Donnie Yance, CN, MH, RH (AHG) – By working with evolutionary dynamics rather than against them, we can develop treatment strategies that are more effective, less toxic, and more sustainable over the long term, opening up entirely new therapeutic possibilities.
By Donnie Yance – Tribulus terrestris represents one of the most extensively researched traditional medicinal plants, with a wealth of scientific evidence, and significant therapeutic potential across multiple systems.
By Geo Espinosa – Prostate cancer remains the second leading cause of cancer death (after lung cancer) in men worldwide, and a recent report has highlighted a surge in clinically significant prostate cancer. Why?
By Geo Espinosa, ND, LAc – In well-selected, well-monitored men, testosterone therapy can improve quality of life—without compromising oncologic outcomes.
By Geo Espinosa, ND, LAc – In men with low testosterone, PSA can underestimate prostate cancer risk, even with aggressive disease. Up to 18% may harbor significant tumors despite “normal” PSA. Clinicians should use MRI, biomarkers, and close monitoring rather than relying on PSA alone.
Rudy Shur – This book is an accessible guide, written for men, to understand, identify, and treat the many common sources of these many ailments, including fatigue, depression, sexual dysfunction, headaches, anger, cancer, nervousness, weight loss/gain, heart disease, male menopause, stress, mood swings, diabetes, sleep apnea, and so much more – all serious disorders that can be life-threatening, if left untreated.
by Geo Espinosa, ND, LAc – Prostatitis remains frustrating for both patients and physicians alike, and success in managing it often lies in looking beyond the prostate—and toward the whole person.
Even with a clean and balanced diet, it’s harder than ever to get optimal nutrient levels. Let food and exercise be the foundation for your health, but let supplements fill in the gaps and help you address specific needs.
It has proven to be difficult, if not impossible, to proceed to full-scale randomized controlled trials (RCTs) for most of the natural methods that cannot be patented or otherwise monopolized.
By addressing food sensitivities through targeted testing and personalized dietary interventions, individuals can take a significant step toward reducing inflammation, improving gut health, and enhancing overall well-being.
As the producer of The Moss Report, the year leading up to the Covid-19 pandemic was filled with anticipation and excitement. We had invested years of hard work and significant resources into two major projects: our feature film, Immunotherapy: The Battle Within, and...
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