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Drugging Our Old Folks

Drugging Our Old Folks

by | May 15, 2022

Post Categories: Aging and Longevity | Mental Health | Perspectives | Pharmaceuticals | Studies/Reviews | Supplements

Elderly people are particularly susceptible to the adverse effects of medications. A meta-analysis of observational studies found that, of 7,533 hospitalizations among people aged 65 years or older, 1,251 (16.6%) were judged to be due to adverse drug reactions.1 Despite these risks, the practice of putting old people on multiple prescription medications is widespread. A 2015 study found that the median number of prescription medicines used by elderly individuals was four, and that 39% of old folks were taking five or more drugs.2 According to one report, the average nursing home patient is taking seven medications.

Drugs that act on the central nervous system (CNS) can be particularly problematic. These medications can impair cognitive function and may increase the risk of fall-related injury and death. Drugs that are considered CNS-active include antidepressants, antipsychotics, antiepileptics/anticonvulsants (e.g., gabapentin [Neurontin]), benzodiazepines, benzodiazepine receptor agonists (e.g., zolpidem [Ambien]), and opioids. The risks associated with CNS-active drugs may be even greater in elderly people with dementia, since these individuals already have impaired cognitive function.

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Author

Alan R. Gaby, MD

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