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Literature Review & Commentary

Literature Review & Commentary

by | Jul 1, 2022

Post Categories: Cardiovascular Health | Diet and Nutrition | Gut Health | Nutrition and Lifestyle | Preventive Care for Children | Studies/Reviews

Gluten and Inflammatory Bowel Disease

The association between gluten intake and risk of developing inflammatory bowel disease (IBD; ulcerative colitis or Crohn’s disease) was examined in a prospective cohort study of 208,280 US participants from the Nurses’ Health Study (1986-2016), Nurses’ Health Study II (1991-2017), and Health Professionals Follow-up Study (1986-2016) who did not have IBD at baseline or celiac disease and who completed food frequency questionnaires. During 5,115,265 person-years of follow-up, 337 new cases of Crohn’s disease and 447 new cases of ulcerative colitis were documented. No significant associations were found between gluten intake and risk IBD. Compared with participants in the lowest quintile of gluten intake (mean, 3.1 g/day), the adjusted hazard ratios for participants in the highest quintile of gluten intake (mean, 8.8 g/day) were 1.16 for Crohn’s disease (p for trend = 0.41) and 1.04 for ulcerative colitis (p for trend = 0.64). The authors concluded that gluten intake was not associated with risk of Crohn’s disease or ulcerative colitis.

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Author

Alan R. Gaby, MD

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