Gut Microbiota in Liver Disease
Gut microorganisms have a direct effect on liver health, according to an article by David A. Brenner and colleagues.1 While chronic alcohol consumption is known to damage the liver, what is less recognized is alcohol’s effect on microbes in the GI tract and how these changes affect the liver. Chronic alcohol consumption boosts intestinal bacterial overgrowth by reducing intestinal antibacterial peptides (particularly Reg 3g) and changes the composition of the gut microbiome. People with cirrhosis have bacterial overgrowth in the small intestine, increased bacteremia, and increased intestinal permeability.










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