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Literature Review & Commentary

by | Nov 1, 2021

Post Categories: Book Reviews | Health Conditions | Integrative Medicine | Preventive Care for Children

Is Ivermectin an Effective Treatment for COVID-19?

The authors reviewed 24 randomized controlled trials involving 3,406 participants that examined the effect of ivermectin in people with, or at high risk of, COVID-19 infection. The trials were conducted in Bangladesh, Nigeria, Pakistan, Spain, Iran, Egypt, Brazil, Mexico, Argentina, Colombia, India, Turkey, Bulgaria, Lebanon, and Israel. Meta-analysis of 15 trials (n = 2,438) that assessed mortality as an outcome found that ivermectin reduced the risk of death by an average of 62% (moderate-certainty evidence). Low-certainty evidence found that ivermectin prophylaxis reduced COVID-19 infection by an average 86%. Low-certainty evidence suggested that ivermectin does not decrease the need for mechanical ventilation, whereas effect estimates for “improvement” and “deterioration” clearly favored ivermectin use. Severe adverse events were rare.

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Author

Alan R. Gaby, MD

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