As all naturopathic physicians are aware, the eclectic physicians of the 1800s and early 1900s have had a profound impact on the way naturopathic physicians of today think and formulate. Today, there is increasing evidence that the approach of combination therapy utilized by the portion of eclectics who favored combination therapy, which is today infused into the naturopathic approach, is a sound way to increase benefit and reduce risk. Below, we review and illustrate the shortcomings of single-therapy pharmacological intervention and the increasingly understood reasons why combination therapy offers increased efficacy and improved safety.
To efficiently illustrate both the shortcomings of monotherapy and the opportunities of combination therapy, it is helpful to dust off a representation of a sigmoidal dose response curve used to depict the pattern of many drugs’ effects, with dose shown along the X axis and percent of the population achieving response along the Y axis, as shown below.










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