Hesperidin for Hypertension?
One hundred fifty-nine Spanish adults (aged 18-65 years) with pre-hypertension or stage 1 hypertension were randomly assigned to receive, in double-blind fashion, 500 ml per day of orange juice (containing 345 mg of hesperidin), orange juice enriched with additional hesperidin (total, 600 mg per day), or a hesperidin-free control drink (contents not specified). At 2, 6, 10, and 12 weeks, compared with the control drink, mean systolic blood pressure was significantly lower with high-dose hesperidin and nonsignificantly lower with low-dose hesperidin. At all time-points, high-dose hesperidin was nonsignificantly more effective than low-dose hesperidin for decreasing systolic blood pressure.










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