The gut microbiome does far more than support digestion. Its influence on intestinal barrier integrity, microbial metabolism, and systemic inflammation is emerging as an important consideration in metabolic health, chronic disease, and healthy aging.  But can targeted microbiome interventions influence the integrity of the intestinal barrier and reduce the production and accumulation of potentially harmful microbial metabolites? And what happens when these mechanisms are tested under conditions of extreme metabolic stress?  This session explores new laboratory and clinical research examining these questions. Recent studies using sophisticated human intestinal simulation models and transepithelial electrical resistance (TEER) measurements provide insights into how probiotic and synbiotic interventions influence microbial metabolism and intestinal barrier function.  The presentation will also feature new 12-month clinical findings from research involving patients with advanced chronic kidney disease—a population experiencing substantial metabolic stress and altered microbial function. Kidney-function biomarkers, metabolic measures, and patient-reported quality-of-life outcomes will be examined to assess the clinical evidence for targeted microbiome interventions.  By connecting laboratory mechanisms with longitudinal clinical research, this session will explore the broader implications of microbiome modulation for intestinal health, systemic metabolic balance, and evidence-informed naturopathic practice. Learning Objectives:    Explain how the gut microbiome influences intestinal barrier integrity, microbial metabolite production, […]