The Anionic-Cationic Imbalance in Women’s Health: How Reams’ Analysis and Nieper Mineral Transporters Restore Energy, Hormones, and Bone Density

The Anionic-Cationic Imbalance in Women’s Health: How Reams’ Analysis and Nieper Mineral Transporters Restore Energy, Hormones, and Bone Density

by | Mar 15, 2026

When asked to write an article that focuses on a specific area of health, my first challenge is to engage the reader to think energy-based concepts vs cellular concepts. From a bio-electric chemistry perspective, optimal health requires that you gain more energy from food and lifestyle than the body consumes in daily function. I’ve written several articles about this in NDNR and Townsend Letter, which I encourage readers to review to aid in thinking energy vs cellular, as nature and natural medicine follow identified laws established in a hierarchy of self that begins with energy and becomes cellular.

Below are biological life energy concepts to which various scientists have established hypotheses to further understand how our bodies work, that I hope to show a hypothetical link to what Dr. Carey Reams tried to teach and make available to all. Again, this information lays the foundation to assist the reader to shift the paradigm from symptom-based gynecology to energy-based, mineral-driven, pH/voltage-driven models using Reams’ Analysis as the measuring tool, and Hans Nieper’s membrane-active mineral salt research to guide in mineral selection where applicable. Reams’ Analysis measures ionic balance (anion/cation rotation, pH drift, conductivity) as real-time indicators of “energy loss” in the body’s bio-electric system, which essentially is a low-tech voltmeter for cellular voltage and ion adsorption.

Scientist / ConceptCore Idea That Supports ReamsHypothetical Link to Reams’ Theory and Mineral Availability
Gilbert Ling (1919–2019)Association-Induction Hypothesis: Cell is not a membrane-pump system but a cooperative matrix of structured water + adsorbed ions (especially K⁺ inside, Na⁺ outside). ATP is not a pump but a “cardinal adsorbent” that changes protein conformation and ion preference.Explains why Reams’ “cation/anion rotation” and low conductivity predict cellular energy failure even when serum electrolytes are normal. Ling showed minerals must be in the correct adsorbed (not dissolved) state.
Harold Saxton Burr (1889–1973)“L-Fields” (Life fields): Every living system is controlled by a measurable direct-current electric field. Field changes precede pathological changes by weeks to months.Reams’ pH and conductivity numbers are indirect measurements of Burr’s L-field polarity and strength. A drifting pH or collapsing conductivity = collapsing L-field long before symptoms or blood tests change.
Fritz-Albert Popp (1938–2018)Biophoton emission: All living cells emit ultra-weak coherent light (200–800 nm). Health = high coherence and low entropy of the photon field. Toxins, low oxygen, and mineral imbalance increase chaotic emission.Reams’ “energy gain/loss” calculation and the ideal 6.4/6.4 zone theoretically would produce the most coherent biophoton signature
Mae-Wan Ho (1941–2016)“Quantum coherent organism”: Liquid crystalline water + collagen + proteins form a body-wide coherent excitation domain. Minerals act as dopants in this living semiconductor.Explains why Reams’ mineral corrections (especially calcium, magnesium, potassium in bioavailable forms) can produce almost instant shifts in energy — you are literally re-doping the body’s liquid-crystal matrix.
Konstantin Korotkov (1952–)Gas Discharge Visualization (GDV) / Electrophotonics: Modern digital version of Kirlian photography that measures the electron/ion cloud around the body in real time.Theoretically when a person reaches Reams’ ideal numbers (6.4/6.4/C=6–8), the GDV electrophotonic glow should become symmetrical, coherent, and minimal in “defect” areas 

Each of the above pioneers describe health as a state of high coherence (e.g., Popp’s low-entropy photons, Burr’s stable L-fields, Ling’s adsorbed ions in structured water, Ho’s coherent quantum organism). Dr. Carey Reams showed that energy shifts toward ideal were based on mineral corrections, which hypothetically that energy shift would logically restore these coherence energy states, as minerals “dope” the system’s conductivity per Mae Wan Ho and aligning with Albert Szent-Györgyi’s Nobel prize-winning work. Szent-Györgyi established that bio-electronic function is a key aspect of many cellular processes, linking them to the subatomic level.

With the above foundation to encourage the reader to think energy, let’s now take this to female physiology and health concerns. Below is a chart that connects minerals to female health. My goal is to show the importance of how anionic-cationic ionic balance, as measured by a Reams’ Analysis, guides in the availability of minerals needed to support these health concerns, and how selective forms of minerals can enhance availability and focus of therapy.

Mineral Connections to Women’s Health

MineralWomen’s Health ConnectionStudy SummaryReference
CalciumOsteoporosis prevention; hormonal aggravation in menopause (e.g., estrogen decline increases bone loss risk).Supplementation with calcium (1,000–1,200 mg/day) + vitamin D reduced fracture risk by ~20% in postmenopausal women; imbalances linked to hot flashes and bone density loss.Hayden Institute Review (2012)
Calcium (Orotate form, per Nieper)Bone recalcification in osteoporosis; superior absorption for joint/cartilage health.Clinical observations showed calcium orotate effective for osteoporotic decalcification and pain relief in spine osteoporosis; 90–95% bioavailability vs. 45% for aspartate.Nieper (1970) & Muhammad et al. (2010)
MagnesiumHormonal balance (PMS, menopause); thyroid conversion (T4 to T3); insulin resistance in PCOS.Mg deficiency linked to menstrual irregularities; 300 mg/day supplementation improved PMS symptoms and T3 levels in hypothyroid women.Nutrients Systematic Review (2024); Mahmoodianfard et al. (2015)
Magnesium (Orotate/Aspartate, per Nieper)Cardiovascular support in perimenopause; counters calcium excess to prevent soft-tissue calcification.Mg orotate mobilized cholesterol in vessels and supported heart health in women with arrhythmias; enhanced intracellular delivery for energy production.Nieper (1985) & Classen (2004)
IronOvulatory infertility; anemia in reproductive years; menstrual cycle regulation.Inverse association between Fe intake and anovulation; deficiency caused hormonal imbalances and reduced ovarian blood flow in healthy cycling women.Chavarro et al. (2018, PMC); Nutrients (2024)
ZincFertility (oocyte quality, PCOS); progesterone synthesis; thyroid function in obesity/hypothyroidism.Zn supplementation (25–50 mg/day) improved ovulation and reduced PCOS symptoms; essential for sex hormone balance and T4-to-T3 conversion.PubMed Systematic Review (2024); Mahmoodianfard et al. (2015)
SeleniumThyroid protection (Hashimoto’s, hypothyroid); ovulation stability; miscarriage risk.Se (100–200 mcg/day) + Zn improved T3/T4 ratios in overweight hypothyroid women; deficiency linked to anovulation and oxidative stress in fertility.Nutrients (2024); Mahmoodianfard et al. (2015)
IodineThyroid hormone synthesis; fertility (anovulation from deficiency); breast health in menopause.Iodine deficiency (<50 μg/g creatinine) caused hypothyroidism and infertility; supplementation (150–250 mcg/day) boosted fertility but excess risked pregnancy complications.Nutrients (2024); Christian et al. (2011, PMC)
Potassium (Aspartate form, per Nieper)PMS bloating (counters sodium); adrenal fatigue in perimenopause; energy in RBTI “Zone 3” patterns.K-Mg aspartate activated ATP enzymes for energy; used in Nieper’s protocols for hormonal stress and low conductivity in RBTI.Nieper (1977) (Limited direct RCTs; practitioner-derived).

Unfortunately, Reams’ theory has become a practitioner-derived framework of information because of limited formal peer-reviewed studies of minerals on hormonal patterns, and it’s rooted in ionic energy concepts and unpublished case studies. Dr. Hans Nieper’s work on specific mineral forms acting as membrane specific enzymatic cofactors is cited in clinical contexts, but often through his own publications or subsequent reviews rather than large clinical controlled trials. I can only attest to personal experiences in observing improvements in nearly every women’s health related concern using Reams’ Analysis as the basis for supplemental support and Nieper’s mineral forms in select cases with specific concerns.

Dr. Hans Nieper’s Mineral Transporters research showed why standard mineral forms (oxides, sulfates, citrates) have poor intracellular delivery in sick or low-voltage cells. Nieper showed that orotates, aspartates, arginates, and 2-AEP (colamine phosphate) have the ability to cross cell membranes independent of ATP-driven pumps, with numerous clinical studies of his success with osteoporosis, PMS bloating, progesterone synthesis, mood stabilization, perimenopause, multiple sclerosis, and cardiac arrhythmias.

Dr. Carey Reams outlined energy ranges, which have been broken down into zones in the following chart. This chart outlines how different RBTI (Reams Biological Theory of Ionization) zones, as indicated by urine and saliva pH (anionic vs cationic ionic shift), impact mineral availability and retention in the body as described by Dr. Reams. Reams outlined that calcium is the controller of all minerals moving in and out of the cells, and that various forms of calcium are deficient and needed to correct ionization and mineral availability. Each zone correlates with specific patterns of mineral imbalance, which can contribute to or exacerbate various women’s health concerns.

Reams’ 7 Zones of Degeneration in Women’s Health

ZonepH Direction (Urine/Saliva)Calcium & Magnesium AvailabilityPhosphorus AvailabilityKey Minerals Lost or Locked UpTypical Women’s Health Pictures Caused or Worsened by Mineral Imbalance
1Extreme Acid (≤5.0 / ≤5.4)Calcium precipitates as insoluble oxalate or phosphate stones, resulting in nearly zero usable calcium.Phosphorus is locked in acids, making it unavailable.There is massive loss of calcium, magnesium, potassium, and sodium from bones and tissues.Associated health issues include advanced osteoporosis, kidney stones, ovarian cysts, breast calcifications, cancers of the breast, ovary, and uterus, tooth decay, severe PMS, and infertility.
2Strong Acid (5.0–5.5 / 5.4–5.8)Calcium remains largely unavailable, as high anion charge draws calcium from bones.Phosphorus starts to be excreted.Calcium, magnesium, zinc, copper, and iodine are leached out.Common health symptoms include fibrocystic breasts, endometriosis, PCOS, heavy and painful periods, migraines, hypothyroidism, hair loss, and fibromyalgia.
3Moderate Acid (5.5–6.0 / 5.8–6.2)Calcium begins to solubilize but remains low; magnesium levels start to drop.Phosphorus levels improve but remain unpredictable.Calcium and magnesium are gradually pulled from bones and teeth.Women may experience PMS, mood swings, ovarian cysts, fibroids, irregular cycles, infertility, easy weight gain, adrenal fatigue and cold hands and feet.
4Optimal Health (6.3-6.6 / 6.3-6.6)Optimal ionization and retention; calcium, magnesium, phosphorus, and potassium are fully available and retained.Phosphorus to calcium ratio is ideal (10:4 in the blood).All minerals are retained and utilized perfectly.This zone supports regular, painless 28-day cycles, fertile cervical mucus, strong bones and teeth, thick hair, stable mood, easy pregnancies, and rapid postpartum recovery.
5Moderate Alkaline (6.8–7.2 / 6.8–7.4)Calcium begins to precipitate as carbonate, causing bones to soften again.Phosphorus becomes excessive relative to calcium.Calcium precipitates in soft tissues, while magnesium and potassium are lost in urine.Symptoms may include hypothyroidism, weight gain (especially around hips and thighs), depression, candida overgrowth, yeast infections, low libido, edema, and cellulite.
6Strong Alkaline (7.4–8.0 / 7.6–8.4)Calcium is almost completely insoluble, depositing in joints, arteries, and breasts.Phosphorus levels are very high, which draws calcium out of bones as a buffer.Calcium, magnesium, zinc, manganese, and boron become locked up or excreted.Health consequences include the return of osteoporosis, breast calcifications, calcification of uterine fibroids, increased risk for leukemia and lymphoma, menopausal hot flashes, insomnia, and anxiety.
7Extreme Alkaline (≥8.0 / ≥8.4)Calcium is completely out of solution, forming “chalk” deposits in tissues.Phosphorus toxicity occurs.There is massive precipitation of calcium, along with depletion of magnesium and potassium.Results may include pathological calcification of heels, shoulders, and breasts, seizures, coma, ovarian or breast tumors, and complete hormonal collapse.

Additionally, Dr. Reams outlined that women of childbearing years need seven times the calcium of their male counterparts; they lose 7-15 times more calcium than a man for the same pH drift due to hormonal cation exchange. These ratios are clinical observations from thousands of Reams tests and have not been duplicated in controlled academic settings. Reams suggested the menstrual cycle is the body’s attempt to rid excess anions to re-balance calcium, and menopause is essentially the female body refusing to lose more calcium when reserves are gone, and not a deficiency of estrogen. Dr. Reams explained everything in energy concepts, but to translate this information into lifestyle it suggests:

  • Refined sugar & high carbs → Zone 1–3 (pulls calcium to buffer acids)
  • Soda (phosphoric acid) & caffeine → massive calcium loss
  • Chronic stress → adrenal burnout with calcium and magnesium loss → Zone 1-2

To bring a woman back into Zone 4 and restore mineral reserves, Reams practitioners classically used:

  • Lemon juice or apple cider vinegar to improve mineral acceptance and assimilation
  • Appropriate calcium/mineral supplements and mineral forms based on Reams’ Analysis
  • Phosphatidylcholine foods (eggs, liver) for improved Ca:P ratio and bile flow/strength
  • Very specific dietary carbohydrate control through appropriate hydration and urine brix analysis to assist in energy efficiency and oxygen availability

Essentially, Dr. Reams suggested that keeping chemistry close to Zone 4 is the only way a woman’s body can keep and correctly use the minerals required for hormonal balance, fertility, strong bones, and graceful aging. When you add the research of Dr. Hans Nieper as mineral transporters, it suggests that these specific mineral salts aid in various women concerns:

  • Calcium-orotate and magnesium-orotate – bone density without soft-tissue calcification
  • Potassium-orotate or aspartate – counters sodium retention and PMS bloating
  • Zinc-orotate – critical for progesterone synthesis and immune modulation
  • Lithium-orotate (low-dose) – mood stabilization in PMDD and perimenopause (2020–2024 reviews show 1–5 mg elemental lithium effective and safe)
  • Selenium aspartate – provides thyroid peroxidase protection
  • Magnesium-potassium aspartate – helps mitral valve prolapse which is common in PMDD, PCOS, Estrogen Dominance, and adrenal sympathetic dominant conditions

As you can see this article outlines that most female health conditions can be approached analytically with a Reams’ Analysis to address mineral availability, energy efficiency, and cellular repair. I could garner hundreds of women’s testimonies that address most women’s complaints corrected using this approach. The information may appear overwhelming but becomes simplistic when you understand the application of a Ream’s Analysis in daily clinical practice, especially in your female patients.

Author

  • Darrell S.C.S. Misak, ND, RPh
    Dr. Darrell S.C.S. Misak, ND, RPh is a WVU Pharmacy graduate that later became a Naturopathic Doctor after earning his degree at National College of Naturopathic Medicine in 2000.  Realizing the pitfalls of traditional medicine and pharmacy, Dr. Misak searched for truth in health, which directed him to naturopathic medicine, and to explain that truth through his 5 Phase Optimal Health Mentality and Bio-Electric Chemistry quantum health understanding.
    Dr. Misak has a goal to teach and equip others to create health awareness and change the world.  He has been published multiple times in Naturopathic Doctor News and Review (NDNR) and Townsend Letter, performs lectures, podcasts, and has done YouTube videos teaching an analytical and quantum Bio-Electric approach of health to optimize personal energy efficiency, correct deficiencies, and observe natural health restoration.
    View all posts

Already Subscribed?

Search

Formatting updates are ongoing for older articles.

Author

Featured Articles

Where are your Clinical Trials?

It has proven to be difficult, if not impossible, to proceed to full-scale randomized controlled trials (RCTs) for most of the natural methods that cannot be patented or otherwise monopolized. 

A Renewed Focus on Self-Help for Healing

As the producer of The Moss Report, the year leading up to the Covid-19 pandemic was filled with anticipation and excitement. We had invested years of hard work and significant resources into two major projects: our feature film, Immunotherapy: The Battle Within, and...

Issue Archives

Event Calendar

  • 2026 Association of Natural Health Conference

    Douglasville Conference Center Douglasville, GA, United States

    "From Practitioner to Leader: Clinical Excellence, Business Mastery & Sustainable Practice" Discover how clinical excellence, business mastery, and sustainable systems can help practitioners grow into confident leaders and build practices designed for long-term impact. Why Attend? Three days of learning, connection, and growth designed for every stage of your practice journey. Learn from Leading Voices Gain insights from top experts in natural health, holistic wellness, and functional medicine. Hands-On Learning Participate in in-depth workshops, real-world case studies, and interactive sessions you can apply immediately. Meaningful Networking Connect with like-minded professionals, students, and exhibitors who share your passion for natural health. Practical Tools & Approaches Explore new strategies and tools to elevate both your practice and your own health journey. Who Should Attend? This conference is built for a wide community of natural health professionals, educators, and advocates - wherever you are in your journey. Licensed & Clinical Practitioners Doctors, chiropractors, acupuncturists, naturopaths, and functional or integrative medicine practitioners looking to sharpen clinical skills and grow into stronger practice leaders. Allied Health Professionals Bio-feedback technicians and other allied practitioners seeking hands-on training and the latest tools in natural and holistic care. Educators & Students Natural health educators and students entering the […]

  • Food as Medicine Global 2026

    Virtual Event

    Join health professionals, farmers, food producers, researchers, educators, nonprofit leaders, chefs, policymakers, community organizers, food advocates, public health practitioners, nutritionists, and other changemakers as we convene to share knowledge, build partnerships, and explore new possibilities for improving health, strengthening communities, and creating more equitable and sustainable food systems. This year’s program features inspiring speakers and practical examples of collaboration at the intersection of food, health, social justice, and planetary well-being. Together, we’ll explore innovative approaches to Food as Medicine, community-led initiatives, nutrition, public health, regenerative agriculture, and equitable access to healthy food. Whether you work in health care, agriculture, food production, education, research, policy, or community development, you will discover new ideas, meaningful connections, and practical strategies to advance healthier, more resilient communities. Virtual  |  Join from anywhere in the world Check out the Program: https://tinyurl.com/Food-as-Medicine-for-All

  • The Midlife Women’s Health Summit: Evidence-Based Menopause Care in the Era of Longevity Medicine

    The Ritz-Carlton, Pentagon City 1250 S Hayes St, Arlington, VA, United States
    Hybrid Event

    Menopause Care in the Longevity Era Longevity medicine is everywhere right now. Supplements, protocols, influencer clinics, patients walking in with questions about interventions their doctors have never heard of. What's missing from most of it is the evidence. The Midlife Women's Health Summit is three days on what the research actually says about menopause care when you add a longevity lens. What works, what doesn't, what's being oversold, and what to tell the patient sitting in front of you. Co-chaired by Lisa Larkin, MD, FACP, MSCP, IF, Jen Gunter, MD, FRCS(C), FACOG, DABPM, ABPMR, and Lauren Streicher, MD, FACOG, MSCP; three of the clearest voices in women's health on separating data from marketing.

    $995 – $1299

Related Posts

Exposure, Activity, Contribution: Reading Epstein-Barr Findings in the Individual Patient

Robert Lamberton, BSc, FNTP – Epstein-Barr virus accounts for roughly 2% of cancers worldwide, approaching 360,000 new cases and as many as 210,000 deaths each year, and about 95% of adults carry it. In the overwhelming majority, it causes nothing at all.

When a test for an agent is positive in nearly everyone, a positive test is not a finding. It is a background condition.

Read More

Before Gerson: The Forgotten Medical History of Coffee Enemas

By Scott Wilson – In 1875, Dr. J.P. Thomas wrote about using coffee enemas for opium and belladonna poisoning. He referred to cases going back to 1858 and 1859 and described coffee enemas as one of the ordinary means of treatment. That word “ordinary” stopped me. He wasn’t describing an experiment. He was describing something physicians already knew.

Read More

0 Comments

Submit a Comment