Kyowa Hakko Receives Patent on L-Citrulline and L-Arginine Combination to Rapidly Increase Blood Flow
Kyowa Hakko Bio Co. Ltd. announces that it has received a patent for the combination of the amino acids L-citrulline and L-arginine. The patent protects the use of L-citrulline and L-arginine in formulations used to rapidly and effectively increase blood L-arginine levels.
L-arginine is an amino acid critical to the production of nitric oxide (NO) in the body. NO helps regulate and improve blood circulation. L-citrulline is a major precursor to L-arginine and has been shown in other studies to increase L-arginine levels, and thus improve NO production.
“We measured blood L- arginine levels and Nitric Oxide levels 40 minutes and 60 minutes after amino acids administration. At both time points, the combination of L-citrulline and L-arginine had a better effect than the single amino acids,” said Ryusuke Nakagiri, senior director of strategic science at Kyowa Hakko USA.
A related animal study published in November 2014 in Biochemical and Biophysical Research Communications showed that L-citrulline plus L-arginine supplementation caused a more rapid increase in plasma L-arginine levels and marked enhancement of NO bioavailability, including plasma cGMP (Cyclic guanosine monophosphate) concentrations, than with dosage with the single amino acids.1
Kyowa Hakko Bio Co. Ltd. manufactures both L-citrulline and L-arginine at its Cape Girardeau, Missouri, facility.
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