Pure Encapsulations Announces Publication of Study on Proprietary Polyphenol Blends

Pure Encapsulations, a leading manufacturer of research-based, hypoallergenic nutritional supplements, is pleased to announce new research findings identifying specific pharmacologic actions on its proprietary fruit and vegetable based polyphenol blends. The study, “Anti-Inflammatory and Neuroactive Properties of Selected Fruit Extracts,” was published in the Journal of Medicinal Food and is the result of a comprehensive research collaboration with Atrium Innovations and the Institute of Nutrition and Functional Foods (INAF) based at Université Laval, Quebec, Canada.

Several Pure Encapsulations formulations containing these unique polyphenol blends were recently introduced in the US. PhytoCardio, a combination of cranberry and blueberry extracts, is found in Cardio-C. PhytoMemory, a blend of strawberry, blueberry and spinach extracts, is found in PS-Plus and CogniMag. PhytoLongevity, a combination of the extracts found in both PhytoCardio and PhytoMemory, is featured in the longevity products RevitalAge and RevitalAgeUltra.*

Lead author Kelly C. Heim, PhD, nutritional pharmacologist at Pure Encapsulations, commented on the implications of these findings, “Polyphenols are clinically valuable protective and therapeutic phytochemicals. As our team characterizes the molecular pharmacology and applications of novel, proprietary blends, a platform of evidence-based products continues to expand. This study is just one example of our commitment to research on the mechanisms of unique anti-inflammatory, cardioprotective and neuroactive polyphenol preparations.”

Specifically, the results indicate that these particular polyphenol blends have specific molecular targets with potential relevance to cardiometabolic and neurological health. PhytoCardio was shown to inhibit IKK-β, which is involved in inflammatory gene expression.* PhytoMemory inhibited prolyl endopeptidase (PEP), which has been previously characterized as a promising therapeutic target for supporting learning, memory, and mood.*

“This research provides a proof of principle behind some of our proprietary polyphenol blends,” says Barry Ritz, PhD, VP of scientific and regulatory affairs at Atrium Innovations, parent company of Pure Encapsulations. “Our comprehensive applied research program includes a series of projects looking at small fruit polyphenols in inflammation, sports nutrition, cardiometabolic health, and cognition. We will continue to publish our work in an effort to support the science behind our products as well as elevate the totality of the evidence for the health benefits of natural products.”

* These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

A business unit of Atrium Innovations Inc. [TSX: ATB], Pure Encapsulations is committed to producing the most complete line of science-based nutritional supplements. Available through health professionals, finished products are pure and hypo-allergenic to optimize the long-term health of the most sensitive patients.* Pure Encapsulations is an industry leader in quality, with an extensive raw material and finished product testing program that includes analysis for identity, potency, environmental contaminants, oxidation and more by certified third party laboratories. Pure Encapsulations manufactures its own products in an FDA-inspected facility that is NSF-GMP registered in the US and GMP certified in Canada, and exceeds the standards of the United States Pharmacopeia (USP) for supplement manufacturing. For additional information, please visit www.PureEncapsulations.com.

Atrium Innovations Inc. is a globally recognized leader in the development, manufacturing, and commercialization of innovative, science-based dietary supplements available mainly through healthcare practitioners and health food and specialized stores. Atrium has over 1100 employees and operates seven manufacturing facilities. Additional information is available at www.atrium-innovations.com.

The Institute of Nutrition and Functional Foods of Université Laval (INAF) boasts Canada’s largest team of researchers dedicated to the study of foods and their components and the role they play in nutrition, health, and the prevention of chronic diseases. Our multidisciplinary and intersectoral research program helps develop innovative nutritional approaches including foods and ingredients that are more effective in promoting health at every stage of life. Some 80 researchers contribute to research at INAF, amongst which is Professor Paul Angers, PhD, a world-renowned chemist who specializes in lipids and phytochemical bioactives.