1. Curtis HH. The immunizing cure of hay fever. Med News. 1900;77:16.

  2. Noon L. Prophylactic inoculation against hay fever. Lancet. 1911;1:1572–1573.

  3. McEwen LM. Ganderton MA. Wilson CW. Black JH. Hyaluronidase in the treatment of allergy. Br Med J. 1967;2:507–508.

  4. McEwen LM, Starr MS. Enzyme potentiated hyposensitization I: The effect of pre-treatment with betaglucuronidase hyaluronidase and antigen on anaphylactic sensitivity of guinea pigs, rats and mice. Int Arch Allergy. 1972;42:152–158.

  5. McEwen LM. Enzyme potentiated hyposensitization II: Effect of glucose, glucosamine, N-acetylaminosugars and gelatin on the ability of beta-glucuronidase to block the anamnestic response to antigen in mice. Ann Allergy. 1973;31:79–83.

  6. McEwen LM, Nicholson M, Kitchen I, White S. Enzyme potentiated hyposensitization III: Control by sugars and diols of the immunological effect of beta-glucuronidase in mice and patients with hay fever. Ann Allergy. 1973;31(11):543–550.

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  7. McEwen LM, Nicholson M, Kitchen I, O’Gorman J. Enzyme potentiated hyposensitization IV: effect of Protamine on the immunological behavior of beta-glucuronidase in mice and patients with hay fever. Ann Allergy. 1975;34:290–295.

  8. McEwen LM. Enzyme potentiated hyposensitization V: Five case reports of patients with acute food allergy. Ann Allergy. 1975;35:98–103.

  9. McEwen LM. A double-blind controlled trial of enzyme potentiated hyposensitization for the treatment of ulcerative colitis. Clin Ecol. 1987;5(2):47–51.

  10. Santa Fe Center for Allergy & Environmental Medicine [website]. www.drshrader.com Accessed July 1, 2014.

  11. Shrader WA. Physician Manual for LDA. Ultra Low Dose Allergen Immunotherapy. November 2008. Available through Dr. Shrader’s office.

  12. Dr. William Shrader offers lectures on LDA at the American Academy of Environmental Medicine (aaemonline.org), and Dr. John Wyckoff at the Pan American Allergy Society (paas.org).

  13. Shrader Jr. WA, McEwen LM. Enzyme potentiated desensitization: A sixteen month trial of therapy with 134 patients. Environ Med. 1993;9(3–4):128–38.

  14. Shrader WA. Treating allergies with EPD immunotherapy. In: Nichols TW, Faass N. Optimal Digestion. Harper-Collins; 1999:370–378.

  15. Saporta D. Efficacy of sublingual immunotherapy versus subcutaneous injection immunotherapy in allergic patients. J Environ Public Health. 2012;2012. Article ID 492405. doi:10.1155/2012/492405.

  16. Saporta D. Changes in peak flow meter values during immunotherapy administration. J Environ Public Health. 2012. Article ID 212867.

  17. Davis WE, Cook PR, McKinsey JP and Templer JP. Anaphylaxis in immunotherapy. Otolaryngol Head Neck Surg. 1992;107(1):78–83.

  18. Cook PR, Bryant JL, Davis WE, et al. Systemic reactions to immunotherapy: the American Academy of Otolaryngic Allergy morbidity and mortality survey. Otolaryngol Head Neck Surg. 1994;110(6):487–493.

  19. Saporta D. Reactions to sub-lingual immunotherapy: an analysis of a group of patients who developed adverse events over a period of 5 years. Does glycerin play a role? Townsend Lett. Epub August/September 2014.

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