Professional Strength Systemic Enzymes for Immune and Joint Suppor

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For more than 60 years, Wobenzym PS has been a trusted name for healthful inflammatory support.^† Developed by leading scientists and used by millions of people worldwide, the family of Wobenzym products has been proven to be safe and beneficial for overall health.^† Backed by decades of clinical research and published studies, Wobenzym PS supplies specific enzymes to the body to support immune function, joint, muscle, and tendon health, as well as normal wound healing.^† Recent clinical data continue to support the role that Wobenzym PS plays in maintaining healthy joint function. Compared to Wobenzym N, Wobenzym PS provides health professionals with a unique blend of enzymes in an enhanced formula with twice the strength of active ingredients bromelain, trypsin, and rutoside.

In the human body, hundreds of chemical reactions occur during normal metabolic processes. Many chemical reactions require significant energy in order to take place and therefore need a catalyst to allow the reaction to proceed. The catalyst acts to lower the energy needed for the reaction to move forward. In the body, enzymes play the role of the catalyst and allow reactions to take place that otherwise would not occur. The enzyme itself is not consumed in this process and can be utilized again and again. Enzymes are relatively unique to each reaction, and different enzymes will catalyze different reactions. Certain combinations of specific enzymes, when properly protected from stomach acid, provide systemic enzyme support. Numerous clinical studies show that Wobenzym PS can support numerous processes in the body, including overall immune support, optimal joint and muscle function, and normal wound healing.^† The international literature reveals that systemic enzyme support is an effective modality for immunomodulation and for support of circulatory, lymphatic, cardiac, neurological, endocrinological, reproductive, liver, bone, joint, muscle, kidney and other tissue function.^†

Wobenzym PS is a systemic enzyme formulation that contains a unique blend of enzymes from both plants and animals that have been clinically studied for supporting numerous processes in the body.^† Systemic enzyme supplements work directly in the body after they are absorbed in the small intestine and are not intended to aid in digestion. Consequently, these enzymes can be utilized to assist the body’s various regulatory and communication systems.^†

Three enteric coated tablets contain bromelain 1350 FIP unit (270 mg), rutoside trihydrate (rutin, 300 mg) and trypsin 4320 FIP unit (from pig, 144 mg). The enteric coating helps the enzymes reach the small intestine, where they can be utilized to assist the body’s various regulatory and communications systems.

Since cytokines are involved in inflammatory processes, the binding to cytokines and the

removal of cytokines by the activated α-2-macroglobulin proteins support a balanced and

properly functioning immune system. When cytokine levels are maintained at their optimal physiologically balanced state, the immune system is best able to play a role in protecting the body and supporting a healthy healing process. ^† Cytokines are signaling proteins and glycoproteins involved in cellular communication. They are produced by a wide variety of cells and are typically subdivided into two categories, Th1 and Th2.

Cytokines such as interferon-gamma (INF-g), tumor necrosis factor-alpha (TNF-a), transforming growth factor beta (TGF-b) and interleukins (IL-2, IL-6, IL-12, IL-4, IL-5, IL-10) are produced de novo in various cells as a direct response to stimulation of the immune system. After the enzymes are absorbed, protease molecules can bind with molecules found within the blood, resulting in the formulation of an α-2-macroglobulin-protease complex. This newly formed complex results in a change in its affinity to bind certain cytokines. Once a cytokine is bound to the protease, the entire complex is able to be eliminated from the body.

A balance between Th1 and Th2 cytokine responses is best for optimal health.^†

Douglas Laboratories, a leading provider of dietary supplements, is proud to offer the systemic enzyme supplement Wobenzym PS. This product contains the authentic German Phlogenzym formula used by health professionals in Europe. Wobenzym PS is exclusively available to health-care professionals. It is offered in the form of enteric-coated tablets and provides a specific formulation of enzymes to the body to help maintain optimal immune function, wound healing, and muscle and tendon structure.^† For more information on Wobenzym PS, visit WobenzymPS.com.

Recommended Dosage

The recommended serving size for the maintenance of good immune and joint function is 3 tablets twice daily; however, this can be increased as recommended by your health-care professional (typically up to 12 tablets a day for short periods of time).

Tablets should be taken on an empty stomach (at least 45 minutes before or 2 hours after a meal) with a glass of water at room temperature or colder. If Wobenzym PS is taken with a warm to hot liquid such as coffee or tea, the enteric coating on the tablets may be compromised. Taking the tablets with milk is not recommended, as milk may disturb the absorption of enzymes within the small intestine.

Contraindications

Warning: If you are pregnant or breast-feeding, suffering from bleeding disorders or liver damage, or taking anticoagulant drugs (such as warfarin) consult a health-care professional before using this product.

Adverse Effects

Some people may experience small digestive disruptions such as diarrhea and excess gas, especially when taking systemic enzymes for the first time or in large doses. These effects can be minimized by taking smaller serving sizes more frequently throughout the day.

Clinical studies assessing the benefits of systemic enzymes suggest that if the amount of enzymes ingested exceeds the body’s need, it is simply excreted through regular bowel movement.

^† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

References

Biziulevicius GA. Where do the immunostimulatory effects of oral proteolytic enzymes (‘systemic enzyme therapy’) come from? Microbial proteolysis as a possible starting point. Med Hypotheses. 2006;67(6):1386–1388.

Klein G, Kullich W, Schnitker J, Schwann H. Clin Exp Rheumatol. 2006 Jan–Feb;24(1):25–30.

Akhtar NM, Naseer R, Farooqi AZ, Aziz W, Nazir M. Clin Rheumatol. 2004 Oct;23(5):410–415.

Kamenícek V, Holán P, Frank P. Acta Chir Orthop Traumatol Cech. 2001;68(1):45–49.

Shahid SK, Turakhia NH, Kundra M, Shanbag P, Daftary GV, Schiess W. J Assoc Physicians India. 2002 Apr;50:527–531.